Research Highlights

Prophylactic acetaminophen or ibuprofen result in equivalent acute mountain sickness incidence at high altitude

Prophylactic acetaminophen or ibuprofen result in equivalent acute mountain sickness incidence at high altitude

Posted 30/06/2017

Acute mountain sickness is a potentially life-threatening illness for sojourners to high altitude (> 2500m). Where pharmacological prophylaxis is indicated, Diamox is the drug of choice, but it has distressing side-effects. This Everest-based, double-blind, randomized controlled trial revealed that paracetamol, like ibuprofen, could potentially replace Diamox for prophylaxis.

First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia

First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia

Posted 13/06/2017

It has been maintained for decades that quinine is the safest drug for treatment of malaria in the first trimester of pregnancy. In the largest analysis of data from Thailand and Africa, artemisinins are reported to be at least as safe as quinine. This will simplify treatment protocols worldwide.

New sequencing method for rotavirus from human fecal samples to help epidemiology and surveillance

New sequencing method for rotavirus from human fecal samples to help epidemiology and surveillance

Posted 30/05/2017

Rotavirus is a complex RNA virus with a genome comprised of multiple segments. The virus causes diarrhoea and extracting pure virus from stool samples limits our ability to sequence its genome. A team led by Professor Stephen Baker developed a new capture/purification method for rotavirus allowing us to perform whole genome sequencing from stool samples for the first time.

Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance

Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance

Posted 25/04/2017

South Asia, which includes Nepal, is a hub for typhoid fever.  Trials conducted in Nepal since 2005 confirm that fluoroquinolones are failing for typhoid fever treatment. The WHO and health ministries in the region recommend fluroquionolones as the drugs of choice for typhoid fever. This recommendation needs to be changed.

Picturing health: making malaria visible in Asia-Pacific

Picturing health: making malaria visible in Asia-Pacific

Posted 07/04/2017

Collaboration between photographer Pearl Gan and Professor Kevin Baird from our EOCRU unit in Jakarta, Indonesia, this photographic project aims to raise public awareness of malaria as a serious health problem for the region by telling the human story of Asia’s invisible malaria burden.

Zoonotic Transmission of mcr-1 Colistin Resistance Gene from Small-Scale Poultry Farms, Vietnam

Zoonotic Transmission of mcr-1 Colistin Resistance Gene from Small-Scale Poultry Farms, Vietnam

Posted 31/03/2017

Using epidemiological and microbiological approaches and sequencing data, this study, led by Prof. Constance Schultsz of the Academic Medical Center and Assoc. Prof. Ngo Thi Hoa, shows that usage of antimicrobials in food animal production selects for antimicrobial resistant bacteria (AMRB) in animals, which increases the risk for faecal colonisation of AMRB in humans.

An epidemic of dystonic reactions in central Africa

An epidemic of dystonic reactions in central Africa

Posted 17/03/2017

An investigation conducted by the international medical organisation Médecins Sans Frontières revealed that over a thousand people in a remote area of the Democratic Republic of Congo suffered toxic effects after ingesting fake diazepam pills. The research was published in The Lancet Global Health with contribution from Prof Paul Newton from IDDO and LOMWRU.

Malaria superbugs threaten global malaria control

Malaria superbugs threaten global malaria control

Posted 03/02/2017

Lead by Professor Arjen Dondorp, researchers have found that a dominant strain of drug resistant falciparum malaria, first detected in 2008 in Cambodia, has spread to other countries in the Greater Mekong Sub-region of Southeast Asia. This causes treatment failure rates for the main falciparum malaria medicines, artemisinin combination therapies (ACTs)

Harmonised Zika virus research protocols published

Harmonised Zika virus research protocols published

Posted 03/11/2016

Six harmonised protocols to capture Zika-related data to help public health professionals, clinicians and clinical researchers to gain a better understanding of the disease has been published on the WHO website. A number of partners - under the leadership of Institut Pasteur and WHO, including ISARIC and CONSISE have contributed to the development of these protocols to address key public health concerns associated with the Zika virus outbreak. The Working Group on ZIKV Harmonized Research, which included Dr Gail Carson and Professor Peter Horby from the Centre for Tropical Medicine and Global Health, published a commentary on the project in the Lancet Global Health yesterday.

Birth attendant training course may be global model for safer birth care in poor communities

Birth attendant training course may be global model for safer birth care in poor communities

Posted 17/10/2016

Training local Karen and Burman women as skilled birth attendants in refugee settings resulted in no adverse perinatal outcomes and many positive outcomes such as a drop in stillbirths and infant deaths and more babies being born in clinics rather than at home, says a new study, led by Professor Rose McGready and published in PLOS ONE.