Differential Phenotypic and Genotypic Characteristics ofqnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria
Vien LTM., AbuOun M., Morrison V., Thomson N., Campbell JI., Woodward MJ., Van Vinh Chau N., Farrar J., Schultsz C., Baker S.
<jats:title>ABSTRACT</jats:title><jats:p>The<jats:italic>qnrS1</jats:italic>gene induces reduced susceptibility to fluoroquinolones in enterobacteria. We investigated the structure, antimicrobial susceptibility phenotype, and antimicrobial resistance gene characteristics of<jats:italic>qnrS1</jats:italic>plasmids from hospitalized patients and community controls in southern Vietnam. We found that the antimicrobial susceptibilities, resistance gene characteristics, and plasmid structures of<jats:italic>qnrS1</jats:italic>plasmids from the hospital differed from those from the community. Our data imply that the characteristics of the two plasmid groups are indicative of distinct selective pressures in the differing environments.</jats:p>