Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial
Simon Mendelsohn (cohort 2015-16), Thomas J Scriba, Andrew Fiore-Gartland, Adam Penn-Nicholson, Humphrey Mulenga, Stanley Kimbung Mbandi, Bhavesh Borate, Katie Hadley, Chris Hikuam, Masooda Kaskar, Munyaradzi Musvosvi, Nicole Bilek, Steven Self, Tom Sumner, Richard G White, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T Malherbe, Razia Hassan-Moosa, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, CORTIS-01 Study Team,
Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy of signature-guided preventive therapy in parallel, using a hybrid three-group study design.