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In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells that recognize antigens presented on non-polymorphic major histocompatibility complex-related 1 (MR1) molecules. The MAIT cells are activated by mycobacteria, and prior human studies indicate that blood frequencies of MAIT cells, defined by cell surface markers, decline during tuberculosis (TB) disease, consistent with redistribution to the lungs.

More information Original publication

DOI

https://doi.org/10.1093/infdis/jiaa173

Type

Alumni publications

Publisher

Oxford Academic

Publication Date

08/04/2020

Volume

222

Keywords

Tuberculosis,