Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

<jats:p>Low hemoglobin oxygen saturation (SpO<jats:sub>2</jats:sub>) is common in Sickle Cell Anemia (SCA) and associated with complications including stroke, although determinants remain unknown. We investigated potential hematological, genetic, and nutritional predictors of daytime SpO<jats:sub>2</jats:sub>in Tanzanian children with SCA and compared them with non-SCA controls. Steady-state resting pulse oximetry, full blood count, transferrin saturation, and clinical chemistry were measured. Median daytime SpO<jats:sub>2</jats:sub>was 97% (IQ range 94–99%) in SCA (<jats:italic>N</jats:italic>= 458), lower () than non-SCA (median 99%, IQ range 98–100%;<jats:italic>N</jats:italic>= 394). Within SCA, associations with SpO<jats:sub>2</jats:sub>were observed for hematological variables, transferrin saturation, body-mass-index<jats:italic>z</jats:italic>-score, hemoglobin F (HbF%), genotypes, and hemolytic markers; mean cell hemoglobin (MCH) explained most variability (, Adj ). In non-SCA only age correlated with SpO<jats:sub>2</jats:sub>. -thalassemia 3.7 deletion highly correlated with decreased MCH (Pearson correlation coefficient 0.60, ). In multivariable models, lower SpO<jats:sub>2</jats:sub>correlated with higher MCH (-coefficient 0.32, ) or with decreased copies of -thalassemia 3.7 deletion (-coefficient 1.1, ), and independently in both models with lower HbF% (-coefficient 0.15, ) and Glucose-6-Phosphate Dehydrogenase genotype (-coefficient 1.12, ). This study provides evidence to support the hypothesis that effects on red cell rheology are important in determining SpO<jats:sub>2</jats:sub>in children with SCA. Potential mechanisms and implications are discussed.</jats:p>

Original publication

DOI

10.1155/2013/472909

Type

Journal

ISRN Hematology

Publisher

Hindawi Limited

Publication Date

2013

Volume

2013

Pages

1 - 6