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This randomized, controlled trial shows that acetaminophen reduces kidney dysfunction and risk of developing acute kidney injury, particularly in severe malaria patients who present with high plasma hemoglobin, supporting the hypothesis that acetaminophen inhibits cell-free hemoglobin-mediated renal tubular oxidative damage.

Original publication

DOI

10.1093/cid/ciy213

Type

Journal

Clinical Infectious Diseases

Publisher

Oxford University Press (OUP)

Publication Date

14/09/2018

Volume

67

Pages

991 - 999