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Baricitinib – an anti-inflammatory treatment for rheumatoid arthritis– is being investigated in the RECOVERY trial, the world’s largest clinical trial of treatments for patients hospitalised with COVID-19, taking place in 177 hospital sites across the UK and with over 33,000 patients recruited so far. As an anti-inflammatory, baricitinib may block the signalling activity of cytokine molecules which contribute to the hyper-inflammatory state seen in severe COVID-19. It is thought that baricitinib may act also have some anti-viral activity. The other treatments currently being investigated in the RECOVERY trial are Regeneron’s antibody cocktail, Aspirin and Colchicine.

Chemical composition of the molecule Baricitinib, C16H17N7O2S

Professor Peter Horby, co-Chief Investigator of the RECOVERY trial, said ‘The COVID-19 pandemic is far from over, in fact it is getting worse, and we need to keep pushing to find better treatments. The fatality rate in patients hospitalised with COVID-19 remains far too high and I believe we can and must bring it down. Baricitinib will be the tenth potential COVID-19 treatment to be tested through RECOVERY and we will continue testing new drugs as fast as we possibly can.’

The full story is available on the RECOVERY website.

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The RECOVERY Trial - two years on

One trial. Over 47,000 participants. Nearly 200 hospital sites, across six countries. Ten results. Four effective COVID-19 treatments. And behind them all, an army of countless researchers, doctors, nurses, statisticians and supporting staff.