Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) is adapting its existing tools, designed for emerging respiratory pathogens, for the current outbreak of global significance. This is an international resource for facilitating the collection of standardised clinical data on patients hospitalised with suspected or confirmed infection with novel coronavirus.

Coronavirus © National Institute of Allergy and Infectious Diseases (NIAID)

On 31st  December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown cause in Wuhan City, Hubei Province of the People’s Republic of China. The etiologic agent has been identified as a novel Betacoronavirus (2019-nCoV). Cases of infection with 2019-nCoV have been detected in travellers to Thailand, Japan, Korea and the US, and, on 19th January, the case numbers reported from China increased significantly. The emerging data suggest that person-to-person transmission is occurring, and there is a threat of further escalation and international spread.

In the past, clinical data on emerging infections have not been collected, standardised, or shared quickly enough to inform the outbreak response and patient care. ISARIC – whose Global Support Centre is hosted by the University of Oxford - has a long-standing programme of work on emerging respiratory pathogens which is being adapted for the current outbreak. 

  • Standardised clinical data collection and curation
    Based on a pre-existing ISARIC global observational study of severe acute respiratory infections (SPRINT-SARI), ISARIC has adapted the case record form (CRF) to assist with the collection of standardised clinical data on patients hospitalised with suspected or confirmed infection with nCoV. This CRF will be made available via WHO and other open-access sources as a global resource for public health purposes. A data management platform will be offered by the ISARIC Global Support Centre.
  • Clinical observational studies
    Based on a pre-existing ISARIC Clinical Characterisation Protocol, the federation is making available an observational clinical protocol (with associated patient information leaflets and consent form) that allows data collection that is harmonised with standardised clinical data collection and curation, and sequential biological sampling for research purposes. A data management platform will be offered by the ISARIC Global Support Centre.
  • Clinical trials of therapeutics
    The federation is working with ISARIC partners and with WHO on developing and implementing clinical trials for therapeutics for 2019-nCoV. These are randomised controlled trial protocols.

This work is being supported by a wide range of ISARIC partners and the ISARIC Global Support Centre, as a global resource. Professor Peter Horby, Executive Director of ISARIC, said:

Patients are at the heart of every outbreak. Our work gives local teams the tools they need to react quickly and effectively to this outbreak, doing vital research to advance understanding and improve patient care.

ISARIC stands by the Principles of Data Sharing in public health emergencies as defined through work led by the funders consortium GloPID-R. As such, ISARIC commits to underpinning implementation of timely data sharing. ISARIC is a global federation of clinical research networks, providing a proficient, coordinated, and agile research response to outbreak-prone infectious diseases. ISARIC’s mission is to generate and disseminate clinical research evidence for outbreak-prone infectious diseases, whenever and wherever they occur. ISARIC is funded by the Wellcome Trust, the UK Department for International Development, and the Bill & Melinda Gates Foundation.

Similar stories

Professors Peter Horby and Guy Thwaites recognised in Queen’s Birthday Honours

The pioneering work of members of the University of Oxford has been recognised in The Queen's Birthday Honours List. The honorands include Professor Peter Horby and six researchers that have played key roles in leading the University’s response to the Coronavirus pandemic, from the development of new vaccines to the discovery of new drug treatments. Professor Guy Thwaites is appointed a Member of the Order of the British Empire.

RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19

The RECOVERY trial was established as a randomised clinical trial to test a range of potential treatments for patients hospitalised with COVID-19. Patients with COVID-19 are at increased risk of blood clots forming in their blood vessels, particularly in the lungs. Between November 2020 and March 2021, the RECOVERY trial included nearly 15,000 patients hospitalised with COVID-19 in an assessment of the effects of aspirin, which is widely used to reduce blood clotting in other diseases. There was no significant difference in the primary endpoint of 28-day mortality

The COVID-19 International Modelling Consortium (CoMo Consortium) enters a new phase

Created in March 2020 to assist policymakers to make use of existing evidence in mathematical and epidemiological models to inform strategies for minimising the impact of COVID-19, the CoMo Consortium brings together mathematical modellers, epidemiologists, health economists and public health experts from more than 40 countries across Africa, Asia and South and North America.

New Pandemic Sciences Centre at the University of Oxford

The University of Oxford announces the launch of a centre of global research collaboration and excellence, the Pandemic Sciences Centre. The need for partnership between academic excellence, industry and public health organisations is one of the key lessons learned from the coronavirus pandemic. This centre will unite disciplines, and sectors, to build agile, equitable partnerships that can tackle complex problems and respond to pandemic threats at any time.

RECOVERY trial named David Sackett Trial of the Year 2020

The RECOVERY trial has been named David Sackett Trial of the Year by the Society for Clinical Trials. The award was presented today at the Society for Clinical Trials’ 42nd Annual Meeting.

AMR and scrub typhus among Chiangrai Unit's research priorities

Which infections are most common in the Chiangrai region? How should we treat them and how can we improve diagnostic? Which strategies are most effective in directing antibiotic treatment? Blog by Carlo Perrone, research physician based at the Chiang Rai Clinical Research Unit in Chiangrai, Thailand.