Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The Universitas Indonesia Faculty of Medicine (FMUI) and the University of Oxford's Eijkman Oxford Clinical Research Unit (EOCRU, embedded with the Eijkman Institute of Molecular Biology, EIMB, and part of the Vietnam/Asia Wellcome research programme) have completed a facility dedicated to the support of the many collaborative clinical research activities between the two universities.

EOCRU team

Hosted by the Department of Parasitology on the FMUI campus in central Jakarta, the Universities of Indonesia and Oxford Clinical Research Laboratory (IOCRL) provides an integrated medium for broader engagement with all of our Indonesian friends and partners in training, education, public engagement, and development of a broader collaborative clinical research agenda in the coming years. The IOCRL facility will be managing three active clinical trials in the coming year:

  • ACT-HIV, assessment of adjunctive dexamethasone therapy for TB meningitis in HIV-infected patients at Cipto Mangungkusomo and Persehabatan Hospitals in Jakarta (Wellcome);
  • INSPECTOR pivotal clinical trial of tafenoquine combined with an artemisinin combination therapy for radical cure of vivax malaria in Indonesian soldiers in East Java (GSK UK, Medicines for Malaria Venture, Geneva, and the Bill & Melinda Gates Foundation);
  • a randomized, double-blind, placebo-controlled trial of live Plasmodium falciparum sporozoite vaccines for prevention of acute P. falciparum and acute and latent Plasmodium vivax malaria in Indonesian soldiers (US Congressionally Directed Medical Research Program & Sanaria Inc., USA).

FMUI faculty members serve as the Principal Investigators of each of these endeavours, along FMUI, EIMB (including EOCRU), Oxford University Clinical Research Unit Viet Nam (OUCRU), and Armed Forces of Indonesia co-investigators and technical staff.

The IOCRL facility, managed by Dr Raph Hamers of Oxford University (Centre for Tropical Medicine & Global Health), serves as the administrative, regulatory, and technical hub for these complex and ambitious trials. This remarkably productive engagement of Oxford University with EIMB and FMUI approaches its tenth year with a sense of deep gratitude to these hosts for their warm Indonesian hospitality, collegiality, friendship, and professionalism.

Similar stories

OUCRU scientists identify combination of biological markers associated with severe dengue

Nguyen Lam Vuong, Sophie Yacoub & colleagues have identified a combination of biological markers in patients with dengue that could predict whether they go on to develop moderate to severe disease. Biomarkers are used to identify the state or risk of a disease in patients; these findings could aid the development of biomarker panels for clinical use and help improve triage and risk prediction in patients with dengue.

What does the Oxford Malaria vaccine mean for Asia?

A trial in infants and toddlers in Burkina Faso showed that experimental malaria vaccine R21/MM confers 77% protection, an unprecedented level and the first malaria vaccine to exceed WHO’s goal of 75% efficacy. While a larger trial is needed to assess its safety and efficacy, R21/MM may substantially reduce child mortality in Sub-Saharan Africa. But this vaccine may be less relevant to Asia Pacific where malaria causes severe morbidity and mortality in all age groups, asymptomatic malaria infections are frequent, and the vaccine may not be effective against P. vivax.

RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalised COVID-19 patients who have not mounted their own immune response

The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial has demonstrated that the investigational antibody combination developed by Regeneron reduces the risk of death when given to patients hospitalised with severe COVID-19 who have not mounted a natural antibody response of their own.

Professors Peter Horby and Guy Thwaites recognised in Queen’s Birthday Honours

The pioneering work of members of the University of Oxford has been recognised in The Queen's Birthday Honours List. The honorands include Professor Peter Horby and six researchers that have played key roles in leading the University’s response to the Coronavirus pandemic, from the development of new vaccines to the discovery of new drug treatments. Professor Guy Thwaites is appointed a Member of the Order of the British Empire.

RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19

The RECOVERY trial was established as a randomised clinical trial to test a range of potential treatments for patients hospitalised with COVID-19. Patients with COVID-19 are at increased risk of blood clots forming in their blood vessels, particularly in the lungs. Between November 2020 and March 2021, the RECOVERY trial included nearly 15,000 patients hospitalised with COVID-19 in an assessment of the effects of aspirin, which is widely used to reduce blood clotting in other diseases. There was no significant difference in the primary endpoint of 28-day mortality

The COVID-19 International Modelling Consortium (CoMo Consortium) enters a new phase

Created in March 2020 to assist policymakers to make use of existing evidence in mathematical and epidemiological models to inform strategies for minimising the impact of COVID-19, the CoMo Consortium brings together mathematical modellers, epidemiologists, health economists and public health experts from more than 40 countries across Africa, Asia and South and North America.