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A recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
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Image credit: Pailin, Thailand. Mehul Dhorda, WWARN
Peter Horby
FRS Peter Horby - Moh Family Foundation Professor of Emerging Infections and Global Health
Brian Angus
BSc, MBChB, DTM&H, FRCP, MD, FFTM Brian Angus - Professor of Practice, Medical Education and Reader in Infectious Diseases
