\n \n\n \n \n \n \n KWTRP\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 08/01/2021. Patient safety is much less well studied in low-resource settings than in higher income settings. Mike English and colleagues suggest how concepts being employed to advance patient safety thinking in higher income settings could be usefully applied by practitioners in low-resource settings. The ability to diagnose system weaknesses should become a core skill for those leading teams, wards, departments or facilities in low-resource settings
\n \n\n \n \n\n \n\n \n \n \n \n MORU\n \n \n \n \n OCGHR\n \n \n \n \n SMRU\n \n \n\n \n\n\n
\n \n \n \nPosted 02/07/2019. Highly efficacious treatment can limit the cumulative deleterious impact of malaria during pregnancy on the mother and fetus. Correct assessment of treatment efficacy with an adequate length of follow up is required. Makoto Saito and colleagues at the Shoklo Malaria Research Unit (SMRU) on the Thailand-Myanmar border suggest that pregnant women need to be followed up longer than the currently recommended duration of follow-up to assess antimalarial drug efficacy.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 29/01/2019. Gail Carson, Peter Horby, Laura Merson and colleagues promote the importance of developing clinical research networks in low-resource settings as a pillar to epidemic preparedness in a Letter to Lancet Global Health. The CTM&GH researchers are focused on developing capacity and partnerships across settings at highest risk of infectious disease outbreaks.
\n \n\n \n \n\n \n\n \n \n \n \n KWTRP\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 07/07/2020. In a country with 25 million newborns, children and adolescents, how many paediatricians are there and where are they? This paper by Mike English and colleagues seeks to start a debate on how to deliver paediatric services in LMIC in the future.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 05/06/2018. Children suffering from malaria and malnutrition might experience diminished height growth when treated for both conditions simultaneously. Philippe Guerin and colleagues found that children treated for both falciparum malaria and uncomplicated severe acute malnutrition in Niger experienced a reduction in height gains while increasing their weight at the same time.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 04/08/2020. Major infectious disease outbreaks are a constant threat to human health; clinical research responses generate evidence to improve outcomes and outbreak control. Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research responses to emergency epidemics. Louise Sigfrid and colleagues review those challenges and identify solutions to address them.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 07/04/2020. Data are needed to track progress towards the target to end preventable deaths of newborns in LMICs. Christiane Hagel and colleagues report on the challenges of neonatal data capture and the wider health information system in LMICs. With use cases from Kenyan hospitals and visualisations of neonatal information flow they show the complex people- and paper-based subsystem of the District Health Information Software, version 2 (DHIS2) - a widely used data platform which forms part of the health information system in LMICs
\n \n\n \n \n\n \n\n \n \n \n \n LOMWRU\n \n \n \n \n MORU\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 01/09/2020. This paper provides an overview of FIEBRE\u2019s activities. The study aims to identify infections that are treatable and/or preventable, to assess antimicrobial susceptibility of bacterial pathogens and to collect qualitative data on care-seeking and treatment behaviours. Paul Newton and colleagues detail clinical and laboratory assessments, data analysis plan, and outline the study\u2019s strengths and limitations.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 29/05/2020. In an emergency, we all look for guidance, be that from experts, trusted authorities or professional bodies. The COVID-19 has been the most significant health care emergency for a generation. And yet the very characteristics of an emergency - uncertainty, time pressure - challenge the ability of experts to respond with the rigour that caused us to turn to them in the first place. In this rapid review, Andrew Dagens, Louise Sigfrid, Peter Horby and colleagues took clinical guidelines published in the early COVID-19 and appraised them. They highlight how international organizations can better produce guidelines for future emergencies.
\n \n\n \n \n\n \n\n \n \n \n \n MORU\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 13/11/2020. Use of antimicrobials in animals and the environment has been established to contribute to the global antimicrobial resistance (AMR), and yet there have been inadequate collaborative efforts to tackle this problem. Sunil Pokharel, Bipin Adhikari and colleagues discuss how and why \u2018One health\u2019 approach is important to tackle antimicrobial resistance.
\n \n\n \n \n\n \n\n \n \n \n \n KWTRP\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 10/01/2020. Our ethnography aimed to describe Nairobi\u2019s inpatient newborn wards and the busy lives of the nurses who work there. They work long hours with little supervision in ill-designed wards, staffed by far too few nurses given the pressing need. Under these difficult conditions, the collective model of nursing that develops reduces nurses\u2019 exposure to stress and anxiety. Jacob McKnight and colleagues describe how these coping methods have implications for the quality of care and limit the potential for a patient-centred approach.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 18/07/2017. The WWARN Vivax Surveyor provides an interactive map that summarises the prevalence and degree of chloroquine resistance in Plasmodium vivax parasites across the world. This tool provides a clear and standardised visualisation of vivax clinical trials to date to inform key international, regional and national monitoring strategies.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 05/02/2019. In this study, the WWARN K13 genotype-phenotype Study Group gathered 18 studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. Results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 19/11/2019. Emergence and spread of antimicrobial resistance can lead us to a dead end! It is important to understand factors to its emergence. In this editorial, Bipin Adhikari and colleagues discuss how to broaden our current gaze at tackling the growing antimicrobial resistance in low- and middle- income countries.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 28/01/2020. Delay in access to health services, diagnosis and treatment completion for TB patients is a major problem in Nepal and can contribute to severity of diseases, antimicrobial resistance, and economic burden. In this large qualitative work, Bipin Adhikari and colleagues discuss the factors impeding the access, diagnosis and treatment completion for TB patients in Nepal.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 23/07/2019. Professor Peter Horby and colleagues at the University of Oxford have compiled data from over 6000 patients to provide a comprehensive clinical description of Ebola virus disease. The team also assessed the quality of the published data and found it to be partial, overlapping, and in many instance non-comparable. For high-threat diseases such as Ebola, the authors recommend the establishment of global, anonymised patient registries as a resource for improving patient care.
\n \n\n \n \n\n \n\n \n \n \n \n LOMWRU\n \n \n \n \n MORU\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 01/10/2019. In the light of the alarming global increase in diabetes, Kartika Saraswati and colleagues at the LOMWRU-IDDO Medicine Quality team found few investigations on the quality of antidiabetics and supplies for self-monitoring of blood glucose. However, poor quality medical products were identified on four continents. This important public health issue should thus be further investigated.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 01/03/2019. Peter Horby and colleagues highlight the essential importance of standardised biological reference materials (such as antibodies) for the development of new diagnostic tests, treatments and vaccines, yet their widespread absence for dangerous diseases such as viral haemorrhagic fevers. They suggest a framework for developing these materials that addresses practical as well as ethical and equity issues
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 12/09/2018. The Infectious Diseases Data Observatory (IDDO) has answered a call from the Editors at Lancet Global Health to inform future policy and expectations on authorship of publications based on secondary use of data. The IDDO position, based on the promotion of equity, effectiveness and sustainability in global health research, serves as an excellent example of the collaborative approach endemic to the Center for Tropical Medicine and Global Health.
\n \n\n \n \n\n \n\n \n \n \n \n OCGHR\n \n \n\n \n\n\n
\n \n \n \nPosted 27/03/2018. This study proposes path for improving surveillance of antimalarial resistance through new technologies to produce molecular assays and capacity strengthening among national reference laboratories. After identifying deficiencies in method standardisation, study authors said a range of affordable techniques, combined with improved access to standardized protocols, training and proficiency testing, could boost surveillance efforts.
\n \n\n \n \n