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\n \n \n \nPosted 13/10/2017. Professor Peter Horby outlines potential epidemics in Africa. It is difficult to predict when and where new epidemics might occur so we can be better prepared and have a proactive response. This modelling is based on information on each virus as well as governance, communication, infrastructure and health care provision. Some areas remain at high risk and would benefit from improved surveillance, diagnostic capabilities and better health systems and local policies.
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\n \n \n \nPosted 04/10/2017. Recruiting 183 acute melioidosis patients and 21 control subjects in order to explore immune factors associated with survival status and diabetes, this study identified two class I HLA alleles associated with increased risk of death during melioidosis. Stronger T cell responses to nine immunodominant antigens were observed in those who survived, with responses to one of these \u2013 GroEL \u2013 observed to be impaired in patients with diabetes.
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\n \n \n \nPosted 09/11/2022. Abdul Imam and colleagues studied the effect on the quality of patient care of prospectively adding extra nursing staff to newborn units in a resource constrained LMIC setting in Kenya and described the relationship between staffing and quality of care.
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\n \n \n \nPosted 11/05/2022. Yingxi Zhao and colleagues used data from a national health facility assessment to understand the capacity of Kenya internship hospital to provide internship training for medical doctors. They highlight the major gaps in staffing, equipment and service availability in those hospitals and call for more stringent and regular review and re-accreditation of internship hospitals to provide appropriate and well-resourced training.
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\n \n \n \nPosted 13/09/2017. Amanda Rojek and Peter Horby published a review aimed at clinicians who may treat patients with Ebola Virus Disease. This review outlines advances in understanding the clinical presentation, outcomes and long term sequelae of the disease, and outlines the status of experimental vaccines and treatments.
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\n \n \n \nPosted 22/08/2017. Selecting and trialling therapeutics for preventing congenital Zika disease is challenging. The target product should be low risk, acceptable to the mother, highly effective in preventing adverse fetal outcomes, and practical for widespread clinical use in resource-limited settings. Professor Peter Horby and fellow researchers discuss strategies for addressing these challenges in a recent paper.
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\n \n \n \nPosted 17/03/2017. An investigation conducted by the international medical organisation M\u00e9decins Sans Fronti\u00e8res revealed that over a thousand people in a remote area of the Democratic Republic of Congo suffered toxic effects after ingesting fake diazepam pills. The research was published in The Lancet Global Health with contribution from Prof Paul Newton from IDDO and LOMWRU.
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\n \n \n \nPosted 03/11/2016. Six harmonised protocols to capture Zika-related data to help public health professionals, clinicians and clinical researchers to gain a better understanding of the disease has been published on the WHO website. A number of partners - under the leadership of Institut Pasteur and WHO, including ISARIC and CONSISE have contributed to the development of these protocols to address key public health concerns associated with the Zika virus outbreak. The Working Group on ZIKV Harmonized Research, which included Dr Gail Carson and Professor Peter Horby, published a commentary on the project in the Lancet Global Health yesterday.
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\n \n \n \nPosted 08/01/2021. Patient safety is much less well studied in low-resource settings than in higher income settings. Mike English and colleagues suggest how concepts being employed to advance patient safety thinking in higher income settings could be usefully applied by practitioners in low-resource settings. The ability to diagnose system weaknesses should become a core skill for those leading teams, wards, departments or facilities in low-resource settings
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\n \n \n \nPosted 02/07/2019. Highly efficacious treatment can limit the cumulative deleterious impact of malaria during pregnancy on the mother and fetus. Correct assessment of treatment efficacy with an adequate length of follow up is required. Makoto Saito and colleagues at the Shoklo Malaria Research Unit (SMRU) on the Thailand-Myanmar border suggest that pregnant women need to be followed up longer than the currently recommended duration of follow-up to assess antimalarial drug efficacy.
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\n \n \n \nPosted 29/01/2019. Gail Carson, Peter Horby, Laura Merson and colleagues promote the importance of developing clinical research networks in low-resource settings as a pillar to epidemic preparedness in a Letter to Lancet Global Health. The CTM&GH researchers are focused on developing capacity and partnerships across settings at highest risk of infectious disease outbreaks.
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\n \n \n \nPosted 07/07/2020. In a country with 25 million newborns, children and adolescents, how many paediatricians are there and where are they? This paper by Mike English and colleagues seeks to start a debate on how to deliver paediatric services in LMIC in the future.
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\n \n \n \nPosted 03/08/2022. Naomi Muinga and colleagues report on a process of implementing a co-designed, paper-based newborn monitoring chart in a network of hospitals in Kenya. While the chart was well-received, challenges with full uptake persist and offer opportunities to strengthen the process as well as future implementations.
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\n \n \n \nPosted 05/06/2018. Children suffering from malaria and malnutrition might experience diminished height growth when treated for both conditions simultaneously. Philippe Guerin and colleagues found that children treated for both falciparum malaria and uncomplicated severe acute malnutrition in Niger experienced a reduction in height gains while increasing their weight at the same time.
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\n \n \n \nPosted 16/11/2021. In response to the Zika epidemic the Research Preparedness Network (REDe) engaged local health research communities to enhance long-term research capacity building. This publication is based on a call to fund research training workshops in Brazil and captures the process and impact of this approach. REDe also developed an implementation toolkit to foster similar initiatives and ultimately contribute to local ownership in global health.
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\n \n \n \nPosted 27/08/2021. Demographic and epidemiological changes have prompted thinking on the need to broaden the child health agenda to include care for paediatric complex and chronic conditions, however such expansion is threatened by workforce shortages. Yingxi Zhao and colleagues reviewed how task sharing could support expanded paediatrics services provision in LMICs, especially beyond acute infectious diseases and malnutrition that are widely and historically shifted.
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\n \n \n \nPosted 04/08/2020. Major infectious disease outbreaks are a constant threat to human health; clinical research responses generate evidence to improve outcomes and outbreak control. Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research responses to emergency epidemics. Louise Sigfrid and colleagues review those challenges and identify solutions to address them.
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\n \n \n \nPosted 07/04/2020. Data are needed to track progress towards the target to end preventable deaths of newborns in LMICs. Christiane Hagel and colleagues report on the challenges of neonatal data capture and the wider health information system in LMICs. With use cases from Kenyan hospitals and visualisations of neonatal information flow they show the complex people- and paper-based subsystem of the District Health Information Software, version 2 (DHIS2) - a widely used data platform which forms part of the health information system in LMICs
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\n \n \n \nPosted 01/09/2020. This paper provides an overview of FIEBRE\u2019s activities. The study aims to identify infections that are treatable and/or preventable, to assess antimicrobial susceptibility of bacterial pathogens and to collect qualitative data on care-seeking and treatment behaviours. Paul Newton and colleagues detail clinical and laboratory assessments, data analysis plan, and outline the study\u2019s strengths and limitations.
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\n \n \n \nPosted 22/02/2022. In many sub-Saharan African countries, including Kenya, the use of mortality and morbidity audits in maternal and perinatal/neonatal care as an avenue for learning and improving care delivery is sub-optimal due to structural, organizational, and human barriers. In this exploratory qualitative study, Joyline Jepkosgei and colleagues examined process-related factors that generally influence M&M audits including health workers\u2019 interactions and their experiences, institutional cultures, and broader health system contextual influences, which remain inadequately explored.
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