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Combination antimalarial therapy is being explored to delay development of resistance to falciparum malaria. This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate. Use of these combinations should be closely monitored.

Original publication

DOI

10.1016/s0035-9203(01)90024-0

Type

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date

09/2001

Volume

95

Pages

517 - 518

Addresses

Department of Pharmacology, University of Cape Town, Cape Town, South Africa. hivunit@bigfoot.com

Keywords

Liver, Humans, Malaria, Falciparum, Sesquiterpenes, Artemisinins, Amodiaquine, Drug Combinations, Antimalarials, Cross-Over Studies, Adult, Female, Chemical and Drug Induced Liver Injury, Artesunate