Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The polymerisation of haemoglobin-derived ferri-protoporphyrin IX (Fe(III)PPIX) to haemozoin (malaria pigment) is a crucial process for intraerythrocytic plasmodia to prevent haem toxicity. It is also the target of in-use antimalarial drugs and newer compounds. This reaction and the inhibition thereof can be reproduced and studied in vitro.

Type

Journal

Parassitologia

Publication Date

09/1999

Volume

41

Pages

205 - 208

Addresses

Istituto di Microbiologia, Università di Milano, Italy. donatella.taramelli@unimi.it

Keywords

Erythrocytes, Cells, Cultured, Animals, Humans, Plasmodium, Heme, Hemin, Hemeproteins, Antimalarials, Oxidation-Reduction, Electrochemistry