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Infrared spectroscopy was used to evaluate the effect of non-iron porphyrins (protoporphyrin IX and haematoporphyrin) on haematin polymerisation to beta-haematin at acidic pH. Both molecules effectively inhibited the reaction, with haematoporphyrin 6 times as active as protoporphyrin IX. We postulated that the interaction between the pi electron system of porphyrin rings leads to the formation of pi-pi adducts, which inhibit polymer elongation in the same way as antimalarial drugs (e.g., chloroquine); the presence of hydroxyl groups able to bind haem iron enhances activity.

Original publication

DOI

10.1016/s0014-5793(97)00533-4

Type

Journal

FEBS letters

Publication Date

06/1997

Volume

409

Pages

297 - 299

Addresses

Instituto di Microbiologia Medica, Università di Milano, Milan, Italy.

Keywords

Humans, Malaria, Falciparum, Hematoporphyrins, Hemin, Protoporphyrins, Chloroquine, Polymers, Hemeproteins, Antimalarials, Spectroscopy, Fourier Transform Infrared, Dimerization