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In the present morphological study, we used electron microscopy (EM) to evaluate the activity of three quinolines upon Plasmodium falciparum strains cultured in vitro. The drugs (namely chloroquine, mefloquine and a new active substance, SF6606) showed common cellular targets (i.e. feeding process, protein synthesis, membrane formation and utilisation) but gave rise to different morphological features. EM as a tool is able to reveal a variety of drug-induced alterations, but it does not seem to supply evidence of a definite mechanism of action. Nevertheless, our observations suggest that each drug acts via several mechanisms, possibly linked to different degrees of parasite susceptibility.

Type

Journal

Microbiologica

Publication Date

01/1989

Volume

12

Pages

15 - 28

Addresses

Department of Infectious Diseases, University of Pavia, Italy.

Keywords

Animals, Plasmodium falciparum, Indoles, Quinolines, Chloroquine, Mefloquine, Antimalarials, Microscopy, Electron, Molecular Structure