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Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.

Original publication

DOI

10.1038/s41541-020-00221-3

Type

Journal

NPJ vaccines

Publication Date

01/2020

Volume

5

Addresses

The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.