Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Botulism and tetanus are diseases caused by neurotoxins produced by Clostridium botulinum and Clostridium tetani, respectively. The bacteria and the toxins they produce are closely related. Both diseases are rare in the UK and the developed world, but tetanus in particular is a major cause of death in the developing world, causing between 100,000 and 200,000 deaths each year. In botulism a descending flaccid paralysis occurs, whereas in tetanus generalized muscle spasms develop. Autonomic nervous system dysfunction can occur in either disease, and in tetanus cardiovascular parameters can fluctuate widely. Early involvement of respiratory muscles means that rapid recognition and prompt institution of supportive measures are important in improving survival.

Original publication

DOI

10.1016/j.mpmed.2021.09.003

Type

Journal

Medicine (United Kingdom)

Publication Date

01/01/2021