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PurposeIn this prospective, multicenter, 14-day inception cohort study, we investigated the epidemiology, patterns of infections, and outcome in patients admitted to the intensive care unit (ICU) as a result of severe acute respiratory infections (SARIs).MethodsAll patients admitted to one of 206 participating ICUs during two study weeks, one in November 2013 and the other in January 2014, were screened. SARI was defined as possible, probable, or microbiologically confirmed respiratory tract infection with recent onset dyspnea and/or fever. The primary outcome parameter was in-hospital mortality within 60 days of admission to the ICU.ResultsAmong the 5550 patients admitted during the study periods, 663 (11.9 %) had SARI. On admission to the ICU, Gram-positive and Gram-negative bacteria were found in 29.6 and 26.2 % of SARI patients but rarely atypical bacteria (1.0 %); viruses were present in 7.7 % of patients. Organ failure occurred in 74.7 % of patients in the ICU, mostly respiratory (53.8 %), cardiovascular (44.5 %), and renal (44.6 %). ICU and in-hospital mortality rates in patients with SARI were 20.2 and 27.2 %, respectively. In multivariable analysis, older age, greater severity scores at ICU admission, and hematologic malignancy or liver disease were independently associated with an increased risk of in-hospital death, whereas influenza vaccination prior to ICU admission and adequate antibiotic administration on ICU admission were associated with a lower risk.ConclusionsAdmission to the ICU for SARI is common and associated with high morbidity and mortality rates. We identified several risk factors for in-hospital death that may be useful for risk stratification in these patients.

Original publication

DOI

10.1007/s00134-015-4206-2

Type

Journal

Intensive care medicine

Publication Date

05/2016

Volume

42

Pages

817 - 828

Addresses

Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Erlanger Allee 103, 07743, Jena, Germany. yasser.sakr@med.uni-jena.de.

Keywords

IC-GLOSSARI Investigators, ESICM Trials Group, Humans, Severe Acute Respiratory Syndrome, Severity of Illness Index, Hospital Mortality, Risk Assessment, Risk Factors, Prospective Studies, Age Factors, Aged, Middle Aged, Intensive Care Units, Female, Male