Magnetic resonance imaging in comatose adults resuscitated after out-of-hospital cardiac arrest: A posthoc study of the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest trial.
Eastwood GM., Bailey M., Nichol AD., Dankiewicz J., Nielsen N., Parke R., Cronberg T., Olasveengen T., Grejs AM., Iten M., Haenggi M., McGuigan P., Wagner F., Moseby-Knappe M., Lang M., Bellomo R., TAME trial investigators None.
BackgroundNeuroimaging with magnetic resonance imaging (MRI) may assist clinicians in evaluating brain injury and optimising care in comatose adults resuscitated after out-of-hospital cardiac arrest (OHCA). However, contemporary international data on its use are lacking.AimThe primary aim was to compare the patient characteristics, early postresuscitation care, and neurological outcomes of patients according to MRI use.MethodsWe performed a posthoc analysis of the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial, a multinational randomised trial comparing targeted mild hypercapnia or normocapnia in comatose adults after OHCA.ResultsAfter exclusions, 1639 patients enrolled in the TAME trial were analysed. Of these, 149 (9%) had an MRI. Compared to non-MRI patients, MRI patients were younger (58.9 versus 61.7 years, p: 0.02), had a longer median time from OHCA to return of spontaneous circulation (30 versus 25 min, p ConclusionsIn the TAME trial, 9% of patients had an MRI during their intensive care unit admission. Among these patients, only 16% had a favourable neurological outcome at 6 months.