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<jats:title>ABSTRACT</jats:title> <jats:p>Tuberculosis is rising in the developing world due to poor health care, human immunodeficiency virus type 1 infection, and the low protective efficacy of the <jats:italic>Mycobacterium bovis</jats:italic> BCG vaccine. A new vaccination strategy that could protect adults in the developing world from tuberculosis could have a huge impact on public health. We show that BCG boosted by poxviruses expressing antigen 85A induced unprecedented 100% protection of guinea pigs from high-dose aerosol challenge with <jats:italic>Mycobacterium tuberculosis</jats:italic>, suggesting a strategy for enhancing and prolonging the efficacy of BCG.</jats:p>

Original publication

DOI

10.1128/iai.73.6.3814-3816.2005

Type

Journal

Infection and Immunity

Publisher

American Society for Microbiology

Publication Date

06/2005

Volume

73

Pages

3814 - 3816