Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
Orr N., Lemnrau A., Cooke R., Fletcher O., Tomczyk K., Jones M., Johnson N., Lord CJ., Mitsopoulos C., Zvelebil M., McDade SS., Buck G., Blancher C., Trainer AH., James PA., Bojesen SE., Bokmand S., Nevanlinna H., Mattson J., Friedman E., Laitman Y., Palli D., Masala G., Zanna I., Ottini L., Giannini G., Hollestelle A., Van Den Ouweland AMW., Novaković S., Krajc M., Gago-Dominguez M., Castelao JE., Olsson H., Hedenfalk I., Easton DF., Pharoah PDP., Dunning AM., Bishop DT., Neuhausen SL., Steele L., Houlston RS., Garcia-Closas M., Ashworth A., Swerdlow AJ.
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10 -13 ; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10 -15 ; OR = 1.50). © 2012 Nature America, Inc. All rights reserved.