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© 2014 Elsevier Ltd. Typhoid (enteric fever) remains a major cause of morbidity and mortality worldwide, causing over 21 million new infections annually, with the majority of deaths occurring in young children. Because typhoid fever-causing Salmonella have no known environmental reservoir, the chronic, asymptomatic carrier state is thought to be a key feature of continued maintenance of the bacterium within human populations. Despite the importance of this disease to public health, our understanding of the molecular mechanisms that catalyze carriage, as well as our ability to reliably identify and treat the Salmonella carrier state, have only recently begun to advance.

Original publication

DOI

10.1016/j.tim.2014.06.007

Type

Journal article

Journal

Trends in Microbiology

Publication Date

01/11/2014

Volume

22

Pages

648 - 655