Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis
Wang L., Ko ER., Gilchrist JJ., Pittman KJ., Rautanen A., Pirinen M., Thompson JW., Dubois LG., Langley RJ., Jaslow SL., Salinas RE., Rouse DC., Moseley MA., Mwarumba S., Njuguna P., Mturi N., Williams TN., Scott JAG., Hill AVS., Woods CW., Ginsburg GS., Tsalik EL., Ko DC.
The substrate of the methionine salvage pathway, methylthioadenosine, is a predictor of death in sepsis patients.