Prabin Dahal reviewed the evolution of statistical methods used to understand and define antimalarial drug efficacy in uncomplicated P. falciparum malaria. The article gives a thorough insight into the historical practices and critically reviews the challenges and limitations associated with current approaches and offers alternative methodologies leading to improved study design and analysis.
Scrub typhus is a serious mite-transmitted and difficult-to-diagnose infectious disease increasingly recognised as a major treatable cause of febrile illnesses with a wider distribution beyond Asia. Despite many limitations on the amount and quality of available reports to date, scrub typhus remains a severely underappreciated tropical disease, deserving more attention.
Professor Phaik Yeong Cheah and colleagues published a paper on the evaluation of a community engagement project using drama in Western Cambodia. They demonstrated that the project was feasible in promoting awareness of malaria prevention and control. Audience members perceived drama as entertaining and as the preferred choice of engagement activity.
Bioinformatics skills have become essential for many research areas and building these skills has many challenges. Dr Etienne de Villiers and colleagues develop the eBioKit as a stand-alone bioinformatics educational and research platform that hosts numerous tools and databases for both bioinformatics research and training in a controlled environment
Antimicrobial resistance is a clear and present threat to international health. Dr Phoebe Williams and Professor Jay Berkley reviewed recent data on antimicrobial resistance among children in sub-Saharan Africa since 2005. Research needs to focus on reporting community versus hospital-acquired infections, including patient outcomes, and needs pragmatic clinical trials.
Professor Stephen Baker recruited more than 3,000 children with severe diarrhoea in high usage, high resistance settings in Ho Chi Minh City, Vietnam. He found that antimicrobial usage did not result in reducing the time of symptoms, and actually prolonged it in most cases.
P falciparum and P vivax malaria in pregnancy both increase stillbirth risk, which is likely to increase as endemicity declines. A study by SMRU and University of Melbourne researchers shows that better P falciparum malaria control efforts could prevent up to 1 in 5 to 8 stillbirths in sub-Saharan Africa.
In a paper published in The Lancet this week (12th October 2017), Professor Peter Horby outlines potential epidemics in Africa. It is difficult to predict when and where new epidemics might occur so we can be better prepared and have a proactive response. This modelling is based on information on each virus as well as governance, communication, ...
Severe malnutrition remains common in low-income countries, principally among young children. It usually arises from poor sanitation and infections, besides food insecurity. This comprehensive review by Professor James Berkley describes how research is needed, using modern clinic and laboratory tools, to better understand changes in metabolism, infections and the immune system to improve treatment.
Melioidosis is a neglected tropical disease estimated to kill 89,000 people a year across tropical regions and a vaccine is urgently required. In this collaboration with Imperial College, Professor Susanna Dunachie report for the first time a link between people with the HLA-B*46 genotype and around a three-fold increased risk of death. Survival from melioidosis is correlated with immune responses to nine key proteins from the causative bacteria, Burkholderia pseudomallei. This gives the foundation for development of an effective vaccine.