- Associate professor
Jonathan’s main research interest is in the design, conduct, analysis and reporting of randomised controlled trials, particularly surgical trials. His specific areas of interest include the specification of the target difference in the sample size calculation, addressing interventional expertise and methods for improving recruitment. Jonathan has extensive experience in systematic reviews of randomised controlled trials and diagnostic research. He has collaborated on numerous projects, including randomised trials, observational and diagnostic studies, methodological projects and systematic reviews in a variety of clinical areas, such as anaesthesia, cardiovascular research, obstetrics and gynaecology, ophthalmology, orthopaedics, primary care, general surgery and urology. Particular methodological contributions have been in the design and analysis of surgical trials (including the handling of surgical expertise and addressing non-compliance to treatment allocation), and also specifying the target difference in definitive ("Phase III") randomised trials. A news article related to the DELTA2 guidance, of which a summary paper was recently published in the BMJ and Trials journals, is available here.
Jonathan leads a programme of his own research and is thelead investigator of the DELTA2 and PARCS projects and co-lead of the NIHR-MRC funded placebo surgery guidance project. Jonathan is a lead statistician within the Oxford Clinical Trials Research Unit (OCTRU) and he oversees a group of five statisticians. His current clinical projects include the grant funded ACL SNNAP, BioYarn, DRAFFT2, MACRO, NINJA, ORIF, PARCS, and TOPKAT. He is a Deputy Director of the Surgical Intervention Trials Unit (SITU). Jonathan supervises a number of postgraduate students based both in Oxford and elsewhere on topics related to trials methodology. He also tutors undergraduate students and teaches and examines postgraduate (DPhil and Masters level) students on the methodology of clinical trials, systematic reviews and the related use of medical statistics. Jonathan also has a number of other internal managerial and budgetary responsibilities. He has also undertaken external consultancy as a medical statistics expert (including legal work).
Jonathan holds a number of external responsibilities. He serves on and chairs Data Monitoring and Steering committees for a number of clinical trials and was recently appointed as a Deputy Editor of Clinical Trials, a member of the Editorial Board of Trials journal and a statistical consultant for the British Journal of Surgery. Other responsibilities include serving on grant funding committees (e.g., for the NIHR's Health Technology Assessment and Research for Patient Benefit programmes) and membership of the IDEAL collaboration's steering group and of the ConDucT-II MRC Hub for Trials Methodology Research.