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Dr Tobias Brummaier

Dr Tobias Brummaier

Vaginal microbiome signatures are predictive of preterm birth

Higher levels Prevotella buccalis and lower levels of Lactobacillus crispatus and Finegoldia accompanied by altered cytokine levels in the local vaginal immune environment were associated with preterm birth. These findings may provide an avenue to early identification of pregnant women at risk of preterm birth. From Kumar et al. Front Cell Infect Microbiol 2021.

Gene expression in preterm deliveries

Preterm neonates from resource-constraint population have a higher risk of mortality, mostly due to the lack of advance neonatal care. Early identification of pregnancies at risk for preterm birth would help mitigating this risk. Gene expression profiling in pregnancy is a powerful tool to detect altered gene expression. Keywords of most commonly observed biological pathways associated with gene expression profiles in preterm birth are shown in this word cloud. From Brummaier et al. Eur J Obstet Gynecol Reprod Biol X 2020

Tobias Brummaier

Research Physician

Tobias is a graduate of the Medical University of Vienna, Austria and has been working as a research physician at the Shoklo Malaria Research Unit (SMRU), which is part of the Mahidol-Oxford Research Unit (MORU) on the Thailand-Myanmar border since 2015.

He holds a Master of Clinical Tropical Medicine from Mahidol University and is currently enrolled the PhD programme of the Swiss Tropical Medicine and Public Health Institute at the University of Basel, Switzerland.

Tobias is involved in daily clinical work, which is one of the pillars SMRU is founded on and he is coordinating research that is designed to translate into a direct benefit for the population served by SMRU. As local coordinator for the Wellcome Trust Innovations Flagship in LMICs, a project that aims to reduce morbidity and mortality of rural febrile illnesses, he is part of the Southeast Asian Community-based Trials Network (SEACTN) and he oversees the Scrub Typhus Antimicrobial Resistance Trial (START), a project in collaboration with the MORU-affiliated satellite tropical medicine research unit in Chiangrai, Thailand.

Tobias research focus however, is high throughput molecular profiling. He established a cohort in which gene expression and microbiome profiling is applied to address significant questions in the field of maternal and child health from early pregnancy to two years of life. His work as PhD candidate is based on data derived from this mother-child cohort and investigates the gene expression signatures in preterm deliveries.

Soil-transmitted helminth infections in pregnancy

Soil-transmitted helminth infections are widespread and affect a large proportion of the local population. Pregnant women are particularly vulnerable as helminth infections increase the risk of anaemia. However, there may also be a protective effect as A. lumbricoides was associated with a reduced risk of miscarriage in a retrospective analysis. These forrest plot show associations between helminth infections and pregnancy outcomes. From: Brummaier et al. PLoS Negl Trop Dis 2021