Global Research on Antimicrobial Resistance (GRAM) brings together researchers from around the world to develop the evidence base for understanding one of our most pressing global health challenges, the threat of antimicrobial resistance (AMR). GRAM estimates the burden of AMR worldwide using data, health statistics and geospatial maps. The team is adapting and refining methodologies established in the Institute for Health Metrics and Evaluation (IHME)'s ongoing Global Burden of Disease (GBD) study to build an evidence base of bacterial AMR across the globe, with corresponding visualisations.
Our work investigates the prevalence of resistance in nine bacterial pathogens, and models covariates relating to the spread of AMR, including global antibiotic consumption and household crowding. GRAM also examines the mortality and morbidity burden of resistance across clinical syndromes from 1990 to the present time in all 204 countries and territories included in the GBD study. These findings, which will be available as interactive data visualisations on the IHME website, will assist the global research community and policymakers in tailoring interventions at the local, national, and international level.