Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs
O’Byrne S., Elliott N., Rice S., Buck G., Fordham N., Garnett C., Godfrey L., Crump NT., Wright G., Inglott S., Hua P., Psaila B., Povinelli B., Knapp DJHF., Agraz-Doblas A., Bueno C., Varela I., Bennett P., Koohy H., Watt SM., Karadimitris A., Mead AJ., Ancliff P., Vyas P., Menendez P., Milne TA., Roberts I., Roy A.
AbstractBy comparing fetal and adult B-lymphopoiesis, the authors identify a prepro–B-cell subset in humans that marks the origin of B-cell lineage commitment in utero.