Established in 1979 as a research collaboration between Mahidol University (Thailand), Oxford University (UK) and the UK's Wellcome Trust, the Mahidol Oxford Tropical Medicine Research Unit (MORU) conducts targeted clinical trials and public health research that aim to discover and develop appropriate, affordable interventions that measurably improve the health of people living in resource-limited parts of the world.
The Mahidol Oxford Tropical Medicine Research Unit's main office and laboratories are located within the Faculty of Tropical Medicine at Mahidol University in Bangkok, Thailand, with MORU Units, study sites and collaborations across Thailand, Asia and Africa.
The core of MORU’s activities remains patient-centred clinical research, and the laboratory, mathematical and economic modelling work, and academic and logistical activities needed to support this.
Our geographically dispersed but integrated network afford us the ability to answer important public health questions in the resource-limited settings in which we work:
- What are the best ways to improve the prevention, diagnosis and treatment of the prevalent infectious and nutritional diseases?
- How can the survival of critically ill patients in these settings be improved?
Antimicrobial drug resistance in pathogenic bacteria and malaria parasites has reached crisis point in Southeast Asia. MORU works to determine:
- How can we best treat patients infected with resistant pathogens?
- What is the best way to reduce antibiotic usage and thus the selective pressure on bacteria?
- What are the most ethical and effective tools and strategies to use in malaria elimination campaigns?
- What are the most prevalent acute febrile illnesses, their causes and most effective treatments?
- How can we improve medicine quality?
MORU’s work has led to strong and lasting collaborations with governments, international health agencies, hospitals, academic colleagues and communities across the globe, and supported the education and professional development of local health staff and medical researchers.
An Affiliated Research Centre (ARC) for the UK’s Open University, MORU hosts post-graduate and post-doctoral students from the University of Oxford (UK), Mahidol University (Thailand) and several other universities from across the globe.
MORU is generously supported with significant funding from the Wellcome Trust, our major funding partner. We also receive funding from other trusts and foundations, governments, and multi-lateral donors.
3 April 2019
How do you go about building all the skills you need at the start of your research career? Cherry Lim from our MORU unit in Bangkok, Thailand, was lucky to find a good mentor who guided her through this journey, but her own ceaseless curiosity and excitement about research were also important.
26 March 2019
Rob van der Pluijm presented encouraging findings from TRAC II trial analyses of Triple Artemisinin Combination Therapies to the All-Party Parliamentary Group on Malaria & NTDs on March 19th in Westminster at the Houses of Parliament.
6 March 2019
Lorenz Von Seidlein tells SciDev.Net that mass drug administration as “presumptive treatment” to clear the parasite reservoir was carried out in eight villages spread across Cambodia, Lao PDR, Myanmar and Vietnam. By the third month, the prevalence of P. falciparum had decreased by 92 % in those villages. Over the subsequent nine months, P. falciparum infections returned but stayed well below baseline levels, showing that MDA can stop transmission of falciparum malaria and reduce its prevalence in SE Asia, where resistance to artemisinin has hampered elimination efforts.
Programmes & Units
- Centre for Tropical Medicine and Global Health @Oxford
- COMRU Cambodia (MORU network)
- EOCRU Indonesia (OUCRU network)
- KIMORU DR Congo (MORU network)
- KWTRP KEMRI-Wellcome Trust Research Programme
- LOMWRU Lao PDR (MORU network)
- MOCRU Myanmar (MORU network)
- MORU Mahidol Oxford Tropical Medicine Research Unit
- OUCRU Nepal (OUCRU network)
- OUCRU Oxford University Clinical Research Unit
- SMRU Thailand (MORU network)
MORU Research Highlights
Posted 04/09/2018. DHA-piperaquine is an important antimalarial recommended by the WHO for the treatment of malaria, and an ideal candidate for mass use in malaria elimination. In a large meta-analysis of ~200,000 subjects, Dr Xin Hui Chan and colleagues find the risk of sudden unexplained death after DHA-piperaquine is extremely low and not higher than baseline, confirming the drug’s safety for the treatment and prevention of malaria.
Posted 24/07/18. A study from Bangkok by Professor Wirichada Pan-Ngum and colleagues shows accessing households for proper spraying was a problem for control dengue outbreaks. In addition, inefficient communications among the sectors from hospital to district offices led to inaccurate or missing patient addresses for spraying. Involving community networks help to improve public engagement with and participation in the programmes.
Posted 17/07/2018. This paper by Professor Stuart Blacksell and colleagues describes the first update to the WHO Laboratory Biosafety Manual in 15 years. The need to update international lab biosafety guidance is part of a broader initiative to globalize biosafety, emphasizing principles and approaches that are accessible to countries spanning a broad range of financial, technical and regulatory resources.
Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
Posted 03/07/2018. Chloroquine, the recommended treatment for vivax malaria, delays but does not prevent relapses. Primaquine is the only widely available drug that prevents relapses but it can induce haemolysis in patients with G6PD deficiency. Cindy Chu and colleagues showed that added to chloroquine, primaquine is very effective for relapse prevention, but should be used alongside quantitative G6PD testing.