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The Oxford University Clinical Research Unit is a large-scale clinical and public health research unit based in Vietnam. We are hosted by the Hospital of Tropical Diseases in Ho Chi Minh City, and the National Hospital for Tropical Diseases in Hanoi. We also have sister units in Kathmandu, and Jakarta. As a Wellcome Programme, we have received considerable support from Wellcome since our establishment in 1991.

Oucru benh vien hospital

Oxford University Clinical Research Unit in Vietnam (OUCRU) was established in 1991 and is one of the Wellcome Asia Programmes. We are based within the Ho Chi Minh City Hospital for Tropical Diseases (HTD), at tertiary referral hospital for infectious diseases for southern Vietnam, under the direction of the Health Service of Ho Chi Minh City and the Ministry of Health. OUCRU also has a base in the capital Hanoi at the National Institute of Infectious & Tropical Diseases (NHTD) and has satellite research units in Kathmandu (Nepal) and Jakarta (Indonesia).

OUCRU has a large clinical and scientific research programme which focuses on the most significant infectious diseases in Vietnam. Many of these are also among the greatest threats to global health in the 21st century. The work covers clinical research and aspects of immunology, host and pathogen genetics, molecular biology, virology, mathematical modelling, bioinformatics, biostatistics, health economics and epidemiology. The research is supported by its extensive Clinical Trials Unit and Data Management Centre. It concentrates on the following core areas:

  • Central nervous system infections
  • Opportunistic infections in HIV
  • Dengue
  • Tuberculosis
  • Influenza / emerging viral infections
  • Malaria
  • Typhoid / enteric infections
  • Antimicrobial resistance

OUCRU has established a formal training programme for Vietnamese and expatriate clinicians and scientists in partnership with HTD in Ho Chi Minh City and NHTD in Hanoi, the Health Services and national universities. The programme includes training courses for postdoctoral scientists and research clinicians, and medical elective placements. In addition, OUCRU offers internationally registered PhD fellowships.

OUCRU promotes better understanding and communication of science and health issues in the social, cultural and historical context of communities. The OUCRU public engagement team aims to bring the local communities together with the scientists by involving them in the research, and by improving understanding of the public’s motivations and perceptions. Initiatives such as science theatre productions and media writing generate dialogue and help to develop appreciation of value and need for scientific research.

Interview with Guy Thwaites, OUCRU director, in 2018:

Interview with Guy Thwaites in 2014:

OUCRU Researchers

OUCRU Research Units

Latest news

World malaria day 2019

Faces of malaria

Today April 25 is World Malaria Day. We would like to highlight a malaria photography project by photographer Pearl Gan, in collaboration with OUCRU in Vietnam and EOCRU in Indonesia. Pearl's malaria project aims to bring visibility to the people and their malaria burden through her photographs of them and their environment. She hopes to humanise the faces of malaria and the malaria problem in the Asia-Pacific to audiences unfamiliar with it.

Oucru photographer in residence recognised by isntd

OUCRU Photographer in Residence recognised by ISNTD

OUCRU Photographer in Residence Pearl Gan has been awarded the International Society for Neglected Tropical Diseases (ISNTD) Festival Award for her submission to the ISNTD Festival Showcase. Pearl submission included seven photographs, and was recognised for its impact on tropical diseases and its broader development goals.

Congratulations to jeremy farrar knighted in the new years honours 2019

Congratulations to Jeremy Farrar, knighted in the New Year's Honours 2019.

Director of Wellcome since 2013, Jeremy Farrar was previously Director of our OUCRU Vietnam programme for 18 years. He has published almost 600 peer-reviewed scientific papers, and mentored many dozens of students and fellows. These honours recognise the outstanding commitment and contribution Jeremy has made to science and medicine, and to improving health for individuals and communities globally.

OUCRU Research Highlights

  • The decline of malaria in Vietnam, 1991-2014

    Posted 10/07/2018. The decline of malaria in Vietnam can largely be attributed to the use of artemisinin-combination therapy (ACT) for case management. Recent analyses from Africa showed that insecticide-treated nets had the greatest effect on lowering malaria prevalence, suggesting that the success of interventions is region-specific. Malaria elimination efforts should focus on both vector control and increased access to ACT.

  • Clinical recommendations for high altitude exposure of individuals with pre-existing cardiovascular conditions

    Posted 19/06/2018. Many people with pre-existing heart problems (including heart attack, pacemaker implantation, arrhythmia), high blood pressure and even past history of a stroke seek advice regarding high altitude travel ( > 2500m) for recreation, meetings or pilgrimages. Dr Buddha Basnyat and colleagues succinctly try to address these conditions at altitude and make reasonable recommendations in the face of limited data.

  • Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens

    Posted 30/05/2018. Drug resistant bacterial infections are becoming a major problem. Genomics has become a fundamental tool for tracking bacteria and provides us with the data and knowledge to begin to initiate a response. Stephen Baker and colleagues discuss how resistant bacteria emerge and spread and outline some approaches and knowledge gaps that can help us tackle this global heath emergency.

  • Emerging coxsackievirus A6 causing hand, foot and mouth disease in Vietnam

    Posted 01/05/2018. Hand, foot and mouth disease is a major public-health issue in Asia. Herein, Dr Tan and colleagues at OUCRU report the first detection of emerging coxsackievirus A6 among hand, foot and mouth disease patients in Vietnam, and document how this emerging virus evolves and spreads in space and time.