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First patients enrolled in new clinical trial of possible COVID-19 treatments

@Oxford Research

Oxford Nuffield Department of Population Health started a new trial of potential treatments for adults patients hospitalised with confirmed COVID-19 with the collaboration of Professor Peter Horby

Many of our researchers work on Coronavirus

Research

Researchers from across the Medical Sciences Division are working hard to combat the COVID-19 crises. With particular strengths in infectious diseases and international health, we are well placed to contribute to better understanding and effectively controlling the epidemic. Many of these researchers are affiliated with the Centre for Tropical Medicine and Global Health

The Nuffield Department of Medicine is supporting global efforts in tackling nCoV

@Oxford Research

NDM is prioritising collaborative projects for front line actions to support global efforts in tackling nCoV. ISARIC has launched a number of international resources available free of charge, through which investigators retain full control of data and samples. Gavin Screaton and Guy Thwaites are looking at neutralising antibody responses. Other NDM researchers work on vaccine development, structure, protective immune response, UK hospital settings and pathogens evolution.

Triple drug combinations effective against drug-resistant malaria

MORU Publication Research

Adding a third anti-malaria drug to current artemisinin-combination therapies (ACTs) provides effective treatment against multidrug-resistant falciparum malaria in Southeast Asia, say Oxford researchers in a study in The Lancet. Using TACTs should extend current malaria drugs so drug-resistant malaria doesn't kill millions more and derail hopes of controlling and eliminating malaria.

The experts who have guided the British public through coronavirus outbreak

@Oxford

Trudie Lang is cited as one of the five main players who have helped restore British faith in the value of experts. Trudie has consistently warned that the medical profession needs to learn lessons from the current coronavirus outbreak: “This is not going to be the last outbreak of a previously unknown disease and we have to strengthen the research capabilities of nations where new diseases emerge but which currently have the poorest ability to respond.”

Oxford joins NIHR Health Protection Research Unit in Emerging and Zoonotic Infections

@Oxford Research

From April 2020, an existing successful Health Protection Research Unit will be bolstered by the addition of collaborators from the University of Oxford. Funded by NHIR, the next phase of the HPRU in Emerging and Zoonotic Infections will build on the work already done by the University of Liverpool, the Liverpool School of Tropical Medicine, and Public Health England.

Analysing malaria treatments in Africa: a comparison of the two front-line treatments

@Oxford Publication Research

A statistical analysis of WWARN data from 4,214 participants across multiple study sites in Africa has been published in BMC Medicine. Results indicate that the local prevalence of resistance-associated markers should be considered when choosing a first-line drug to ensure optimal duration of protection.

MsC IHTM annual visit to the Houses of Parliament

Conferences & meetings

On the 11th February the MsC IHTM students visited the House of Parliament and presented their policy briefs in the House of Lords.

Outbreak: fighting coronavirus

@Oxford Research

What do a mathematician, an epidemiologist, a vaccine developer, a protein crystallographer and a whole bevy of immunologists and infectious disease specialists have in common? Answer: they’re just some of the Oxford University researchers coming together to fight the novel Coronavirus outbreak. Science blog by Charvy Narain

Women and Girls in Science Day 2020

@Oxford

The International Day of Women and Girls in Science recognises and celebrates the critical role played by women but also aims to promote their full and equal access to participation in science. However, despite more women than ever working across the sciences, it is still a male-dominated field with only 30% of female researchers, according to UNESCO. IDDO asked colleagues across their networks for their views. How we could encourage more women into science? And what changes are needed in order to keep them in science?

International research consortium activates clinical study for novel coronavirus in England and Scotland

@Oxford Research

In response the novel coronavirus emergency, the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) has activated its Clinical Characterisation Protocol (CCP) for emerging infections in England and Scotland.

Policy Maker’s guide for adopting a gender lens in health systems policy

KWTRP Publication Research

Policy makers are interested in practical steps to a more gender-equitable and transformative health system. A guide published by Research in Gender & Ethics aims to help policy makers adopt a gender lens in policy deliberations on health systems. In order to prompt reflections on how gender affects health systems, we include case studies from Cambodia, Democratic Republic of Congo, Kenya, Liberia, Malawi, Sierra Leone, South Africa, Tanzania and Uganda.

Action needed to ensure research is carried out ethically in global health emergencies

@Oxford Research

Governments, funders, and research bodies must take action to ensure that research is undertaken ethically during global health emergencies, says a new report from the Nuffield Council on Bioethics.

Coronavirus outbreak knowledge hub

@Oxford Research

This pop-up space for 2019 Novel Coronavirus (2019-nCoV) supports evidence generation by pooling protocols, tools, guidance, templates, and research standards generated by researchers and networks working on the response to this outbreak. Findings from previous outbreaks, largely obtained during MERS and SARS outbreaks, are also available. We aim to make research faster and easier, and to enable standardised, quality data to be collected and prepared for sharing.

Clinical research federation responding to the Wuhan novel coronavirus outbreak

@Oxford Research

The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) is adapting its existing tools, designed for emerging respiratory pathogens, for the current outbreak of global significance. This is an international resource for facilitating the collection of standardised clinical data on patients hospitalised with suspected or confirmed infection with novel coronavirus.

Stepping up to the challenge: studying drug dosage during an Ebola outbreak

@Oxford Publication Research

A specialist technique used to study drugs has been completed for the first time during an outbreak of Ebola virus disease.

Art exhibition on substandard and falsified medicines comes to Bangkok

MORU Public Engagement

When we are ill, we expect our medicines to work as intended. But what if they do not contain the ingredients listed on the packaging? The Pharmacide Arts exhibition “What’s in your medicines?” showcases the original artwork of 11 South East Asian artists. The exhibition is open to the public from 26th-28th January 2020 at the Mandarin Hotel, Bangkok, from 10 am – 5 pm.

Global study highlights the extent and impact of drug-resistant enteric fever and the urgent need for new approaches

@Oxford Publication Research

A new study conducted by Christiane Dolecek and colleagues analysed data on antimicrobial resistance of the bacteria Salmonella Typhi and Salmonella Paratyphi, from around the globe, spanning the time from 1990 to 2018. The study highlights the impact of drug resistance and the urgent need for interventions.

Sophie Yacoub nominated Emerging Leader in Infectious Diseases

Awards & Appointments OUCRU

In recognition of her past contributions to the field of international infectious diseases and in anticipation of her future impact on the discipline, Sophie Yacoub, Dengue Research Group Head at OUCRU, Ho Chi Minh City, Vietnam, is recognised as ISID Emerging Leader in International Infectious Diseases.

New insights into our multi-millenia battle with malaria

General Publication Research

Science Blog - George Busby of Oxford University's Big Data Institute discusses his team's research into human genetic resistance to malaria and humanity's age-old struggle against the disease.

Typhoid vaccine over 81% effective in tackling disease in Nepal

OUCRU Publication Research

A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting. OUCRU-Nepal Professor Buddha Basnyat took part in this study.

Picturing health: dengue in Vietnam published in The Lancet

OUCRU Publication

Earlier this year, OUCRU Photographer in Residence Pearl Gan conducted a project focusing on dengue. In that project, she took photos of dengue patients and health care workers at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam. She also took photos of dengue patients in their homes and at research sites in the city. This project was funded by the Wellcome Trust, and this week selected photos from that project have been published in The Lancet as a photo story.

Oswaldo Cruz Foundation launches online knowledge hub on The Global Health Network

@Oxford

Oswaldo Cruz Foundation (Fiocruz) is a leading institution of science and a public health in Latin America. The new online knowledge hub launched on 3rd December 2019 and feature virtual courses, information and news about the Foundation.

KWTRP highlights health equity issues during Equity Week

Conferences & meetings KWTRP

Convened by the International Budget Partnership, Equity Week brings together stakeholders from national and county government, community groups and other agencies to reflect on equity and equality issues particularly in resource mobilization and distribution in the country. KWTRP highlighted issues of disability, access to healthcare, financial risk protection, mapping variations and vulnerabilities in young children

The practice and ethics of participatory visual methods for community engagement in public health and health science

OUCRU Publication

Mary Chambers (OUCRU Public Engagement Vietnam) and Gill Black (Sustainable Livelihood Foundation, South Africa) have partnered with The Global Health Network training centre to published this online course and handbook

Joel Tarning wins Ashford award at ASTMH 2019

Awards & Appointments MORU

Professor Joel Tarning received a Bailey K. Ashford Medal at the ASTMH 2019 Conference. The medal is awarded annually for distinguished work in tropical medicine by an early- to mid-career ASMTH member. Joel is Head of Clinical Pharmacology at MORU and his work focuses on applying pharmacokinetic-phamacodynamic modelling to optimise antimalarial drug therapies, in particular for at-risk groups such as malnourished children and pregnant women.

Oxford named best for medicine for ninth consecutive year

@Oxford Awards & Appointments General

Oxford University has been ranked as the world's best institution for medical and health teaching and research for the ninth consecutive year in the latest Times Higher Education World University Rankings. The ranking is based on criteria measuring teaching, research, industry income, international outlook and citations, which are combined to provide a comparison of universities worldwide.

New LIFE VR immersive education launched

@Oxford KWTRP Research

Life-saving Instruction for Emergences (LIFE), a virtual reality (VR) medical training platform developed by doctors, nurses and researchers at the KEMRI-Wellcome Trust Research Programme (KWTRP) in Kenya and Oxford University with support from HTC, has officially launched today. This new virtual reality medical training app uses HTC VIVE Focus Plus for training doctors and nurses to save lives.

Call for global action on medicine quality

@Oxford MORU Publication

Noting that substandard and falsified medical products (including medicines, vaccines, biologics, and diagnostics) represent a significant and growing threat to human health, The Lancet Global Health published 'The Global access to quality-assured medical products: the Oxford Statement and call to action'. The Oxford Statement has been signed by 159 attendees at the 2018 Oxford Conference on Medicine Quality and Public Health from governments, multilateral agencies, academia and civil society.

Male and female healthcare managers in Kenya: career trajectories and experiences

KWTRP Publication

Women continue to be under-represented in leadership positions across a range of sectors and geographic regions. In the health sector specifically, women comprise a substantial proportion of the global health workforce but are over-represented in lower-paying, lower-status occupations. The role of gender in healthcare leadership in LMIC settings remains under-researched. KWTRP undertook a study to understand and explore career progression and experiences of healthcare leaders at sub-national level in Kenya.

MSc in International Health and Tropical Medicine well represented at the Medical Sciences Divisional 2019 Teaching Awards

@Oxford Awards & Appointments

Congratulations to Proochista Ariana (Major Educator Award), Kevin Marsh (Lifetime Achievement Award), Caroline Jones (Excellent Supervisor Award), Vicki Marsh (Excellent Teacher Award), Prabin Dahal (Early Career Excellent Teacher Award), and Judy Irving (Learning Support Award) who were recognised at the 2019 Teaching Excellence Awards Ceremony, at Merton College on Wednesday 23 October.

Artists explore the problems of poor quality and fake medicines

@Oxford MORU Public Engagement

When we are ill, we trust that the medicines that we take will make us feel and be better. But what if our pills do not contain the ingredients listed on the packaging? The art exhibition ‘What’s in your medicines?’ explores how substandard and falsified (‘fake’) medicines can affect our health, by showcasing the striking and original artwork of 12 South East Asian artists.

Pearl Gan, photographer in residence at OUCRU in Vietnam and EOCRU in Indonesia wins FIGO's 2019 photo competition

Awards & Appointments OUCRU

A mother and her baby leave a Puskesmas - a government-mandated primary care clinic - in West Java, Indonesia, following a check-up. The woman smiles, as the infant stares out from the safety of a bright sarong wrap. This quiet moment of active participation in their own health and well-being is the realisation of a fundamental human right. WHO’s vision for primary health care in the 21st century is to ensure the highest possible level of health and well-being, with equitable distribution.

Congratulations new TropMed professors

@Oxford Awards & Appointments KWTRP MORU

Oxford Medical Sciences Divisional Panel has conferred the title of Professor on three members of our Centre. Ben Cooper - Professor of Epidemiology, Sassy Molyneux - Professor of Global Health and Piero Olliaro - Professor of Poverty Related Infectious Diseases were awarded these titles in recognition of their distinction in their respective fields and contributions to the research, teaching and administration of the Department and we congratulate them on their success!

New research supports co-administration of primaquine with artemisinin-based combination therapies for P. vivax malaria

MORU Publication Research

An individual patient data meta-analysis of 2,017 patients from 19 studies has found a high risk of recurrence following treatment of P. vivax malaria with artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) unless they are co-administered with primaquine. The research supports recommendations that these artemisinin-based combination therapies (ACT) should be combined with primaquine.

Science blog: All things Africa in Oxford: Africa Oxford Initiative

@Oxford

The Africa Oxford Initiative (AfOx) is a cross-university network that brings the University of Oxford’s long-standing, multi-disciplinary engagement with Africa under one platform. The overarching goal of AfOx is to ensure Africa remains a strategic priority for the University, and that students and academics who attend from the Continent feel supported and at home while they are here.

Nobel Prize for Medicine awarded to NDM Professor Sir Peter Ratcliffe

Awards & Appointments General

Professor Sir Peter J Ratcliffe, Director for the Target Discovery Institute within the Nuffield Department of Medicine at Oxford University and Director of Clinical Research at Francis Crick Institute, London, has today been announced as a winner of the Nobel Prize in Physiology or Medicine.

NEST360 partnership to reduce by half newborn mortality in sub-Saharan hospitals

@Oxford KWTRP Research

The Oxford based OHSCAR team is delighted to be a partner the NEST360 project working with KEMRI-Wellcome and the Kenya Paediatric Research Consortium in Kenya to support this effort to improve care care of the sick newborn and save lives

Oxford students celebrate Black History Month

@Oxford General

Oxford University is running a campaign to celebrate Black History Month. Throughout October the university will amplify the annual celebration with a series of content streams and events recognising and appreciating the contributions that BME communities make to society and the university itself. From academics to students, staff and alumni, the campaign will shine a light on black people’s achievements, and echo the growing call for inclusion in all areas of life from education to cultural appreciation.

Oxford Vice-Chancellor Louise Richardson visits MORU and SMRU

MORU

MORU and SMRU were delighted and honoured to host the University of Oxford Vice-Chancellor Prof Louise Richardson and her party during her visit to Thailand on 1-4 September. Accompanying the Vice-Chancellor were Jeremy Woodall (Director of Development (Asia)), Frewyeni Kidane (Fundraiser for Southeast Asia), Cher Wu (Asia Development office) and Ed Gibbs (NDM Director of Finance and Operations).

Report on the state of governance and coordination for health emergency preparedness and response

@Oxford Research

This report presents research on the current state of governance and coordination of health emergency preparedness and response. It highlights key challenges to address for the future. The report was commissioned by the Global Preparedness Monitoring Board to inform their inaugural report launched on 18th September 2019.

MORU's new Critical Care Asia Network: 42 ICUs in 9 countries

MORU Research

In partnership with the Wellcome Innovations Flagship Programme, MORU launched its Critical Care Asia Network project with its first investigators’ meeting on 19-20 Aug in Bangkok. The project will establish an Asian ICU network across 42 ICUs in nine countries and implement a setting-adapted electronic registry.

Oxford Tropical Medicine awarded two RSTMH medals

@Oxford Awards & Appointments KWTRP

Two researchers from the Centre for Tropical Medicine and Global Health were awarded medals by the Royal Society of Tropical Medicine and Hygiene at the 2019 European Congress on Tropical Medicine and International Health. Professor David Warrell was awarded the Sir Patrick Manson Medal, and Dr Samson Kinyanjui the Chalmers Medal.

Tungiasis (Jiggers): How remote village is winning the war

KWTRP Research

In Kenya, the poorest of the poor carry the highest burden of disease. From locally-made, low-cost herbal remedies to affordable hard floors for households, researchers and communities are developing new ways to deal with jiggers in Kenya. Lynne Elson, a research fellow at KEMRI Wellcome Trust, lead a study to determine whether neem and coconut oil reduce inflammation, pain and itching better than the standard treatment in seven days.

Oxford ranked world’s best university for fourth year running

Awards & Appointments General

Oxford has been named the world’s number one university for the fourth successive year in the Times Higher Education World University Rankings.

Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

KWTRP Research

Human trials of new antimalarial drugs are in the pipeline after KEMRI scientists successfully used bacteria to kill the parasite that causes the disease. Trials in Burkina Faso showed that Ivermectin, a conventional drug used for parasitic diseases including river blindness and elephantiasis, reduced transmission rates. The medication worked by making the blood of people who were repeatedly vaccinated lethal to mosquitoes. The study also found that Ivermectin can kill plasmodium falciparum, the malaria parasite carried by female mosquitoes, when administered to humans.

The 'impossible' job of being a neonatal nurse

KWTRP Publication Research

The provision of high-quality care to sick newborns presents challenges in any health system. International guidelines suggest that even for babies who do not require intensive care, there should be one nurse for every 2 – 4 sick babies. However, recent studies conducted in Nairobi show that one nurse takes care of between 20 – 40 newborns. In a recently published policy brief the KEMRI Wellcome Trust programme highlights the experience of nurses in Nairobi’s New Born Units.

New Chagas collaboration to aggregate and standardise data

@Oxford Research

IDDO has launched a new global Chagas scientific collaboration with the Drugs for Neglected Diseases initiative (DNDi). The new platform will collate and standardise data to accelerate better treatments for the 6–7 million people worldwide with Chagas disease.

Ongoing research at KWTRP Nairobi Hub

KWTRP Research

The Nairobi Programme at KEMRI Wellcome Trust Research Programme hosts over 17 principal researchers, 15 PhD fellows and a dedicated team of over 40 research assistants spanning clinical research, health services research, population health research, and health systems and economics research. Learn more about the ongoing research and the principal researchers behind the work.

Latest research finds primaquine improves haemoglobin by day 42 following treatment of P. vivax malaria

@Oxford Publication Research

An IDDO/WWARN study has found that primaquine is not associated with increased levels of anaemia following treatment of patients without G6PD deficiency for P. vivax malaria and should be used as part of a radical cure. In the largest study of its kind to date, researchers carried out a systematic review and individual patient data meta-analysis which involved 3,421 patients in 29 studies published in BMC Medicine.

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