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Typhoid vaccine over 81% effective in tackling disease in Nepal

OUCRU Publication Research

A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting. OUCRU-Nepal Professor Buddha Basnyat took part in this study.

Picturing health: dengue in Vietnam published in The Lancet

OUCRU Publication

Earlier this year, OUCRU Photographer in Residence Pearl Gan conducted a project focusing on dengue. In that project, she took photos of dengue patients and health care workers at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam. She also took photos of dengue patients in their homes and at research sites in the city. This project was funded by the Wellcome Trust, and this week selected photos from that project have been published in The Lancet as a photo story.

Oswaldo Cruz Foundation launches online knowledge hub on The Global Health Network

@Oxford

Oswaldo Cruz Foundation (Fiocruz) is a leading institution of science and a public health in Latin America. The new online knowledge hub launched on 3rd December 2019 and feature virtual courses, information and news about the Foundation.

KWTRP highlights health equity issues during Equity Week

Conferences & meetings KWTRP

Convened by the International Budget Partnership, Equity Week brings together stakeholders from national and county government, community groups and other agencies to reflect on equity and equality issues particularly in resource mobilization and distribution in the country. KWTRP highlighted issues of disability, access to healthcare, financial risk protection, mapping variations and vulnerabilities in young children

The practice and ethics of participatory visual methods for community engagement in public health and health science

OUCRU Publication

Mary Chambers (OUCRU Public Engagement Vietnam) and Gill Black (Sustainable Livelihood Foundation, South Africa) have partnered with The Global Health Network training centre to published this online course and handbook

Joel Tarning wins Ashford award at ASTMH 2019

Awards & Appointments MORU

Professor Joel Tarning received a Bailey K. Ashford Medal at the ASTMH 2019 Conference. The medal is awarded annually for distinguished work in tropical medicine by an early- to mid-career ASMTH member. Joel is Head of Clinical Pharmacology at MORU and his work focuses on applying pharmacokinetic-phamacodynamic modelling to optimise antimalarial drug therapies, in particular for at-risk groups such as malnourished children and pregnant women.

Oxford named best for medicine for ninth consecutive year

@Oxford Awards & Appointments General

Oxford University has been ranked as the world's best institution for medical and health teaching and research for the ninth consecutive year in the latest Times Higher Education World University Rankings. The ranking is based on criteria measuring teaching, research, industry income, international outlook and citations, which are combined to provide a comparison of universities worldwide.

New LIFE VR immersive education launched

@Oxford KWTRP Research

Life-saving Instruction for Emergences (LIFE), a virtual reality (VR) medical training platform developed by doctors, nurses and researchers at the KEMRI-Wellcome Trust Research Programme (KWTRP) in Kenya and Oxford University with support from HTC, has officially launched today. This new virtual reality medical training app uses HTC VIVE Focus Plus for training doctors and nurses to save lives.

Call for global action on medicine quality

@Oxford MORU Publication

Noting that substandard and falsified medical products (including medicines, vaccines, biologics, and diagnostics) represent a significant and growing threat to human health, The Lancet Global Health published 'The Global access to quality-assured medical products: the Oxford Statement and call to action'. The Oxford Statement has been signed by 159 attendees at the 2018 Oxford Conference on Medicine Quality and Public Health from governments, multilateral agencies, academia and civil society.

Male and female healthcare managers in Kenya: career trajectories and experiences

KWTRP Publication

Women continue to be under-represented in leadership positions across a range of sectors and geographic regions. In the health sector specifically, women comprise a substantial proportion of the global health workforce but are over-represented in lower-paying, lower-status occupations. The role of gender in healthcare leadership in LMIC settings remains under-researched. KWTRP undertook a study to understand and explore career progression and experiences of healthcare leaders at sub-national level in Kenya.

MSc in International Health and Tropical Medicine well represented at the Medical Sciences Divisional 2019 Teaching Awards

@Oxford Awards & Appointments

Congratulations to Proochista Ariana (Major Educator Award), Kevin Marsh (Lifetime Achievement Award), Caroline Jones (Excellent Supervisor Award), Vicki Marsh (Excellent Teacher Award), Prabin Dahal (Early Career Excellent Teacher Award), and Judy Irving (Learning Support Award) who were recognised at the 2019 Teaching Excellence Awards Ceremony, at Merton College on Wednesday 23 October.

Artists explore the problems of poor quality and fake medicines

@Oxford MORU Public Engagement

When we are ill, we trust that the medicines that we take will make us feel and be better. But what if our pills do not contain the ingredients listed on the packaging? The art exhibition ‘What’s in your medicines?’ explores how substandard and falsified (‘fake’) medicines can affect our health, by showcasing the striking and original artwork of 12 South East Asian artists.

Pearl Gan, photographer in residence at OUCRU in Vietnam and EOCRU in Indonesia wins FIGO's 2019 photo competition

Awards & Appointments OUCRU

A mother and her baby leave a Puskesmas - a government-mandated primary care clinic - in West Java, Indonesia, following a check-up. The woman smiles, as the infant stares out from the safety of a bright sarong wrap. This quiet moment of active participation in their own health and well-being is the realisation of a fundamental human right. WHO’s vision for primary health care in the 21st century is to ensure the highest possible level of health and well-being, with equitable distribution.

Congratulations new TropMed professors

@Oxford Awards & Appointments KWTRP MORU

Oxford Medical Sciences Divisional Panel has conferred the title of Professor on three members of our Centre. Ben Cooper - Professor of Epidemiology, Sassy Molyneux - Professor of Global Health and Piero Olliaro - Professor of Poverty Related Infectious Diseases were awarded these titles in recognition of their distinction in their respective fields and contributions to the research, teaching and administration of the Department and we congratulate them on their success!

New research supports co-administration of primaquine with artemisinin-based combination therapies for P. vivax malaria

MORU Publication Research

An individual patient data meta-analysis of 2,017 patients from 19 studies has found a high risk of recurrence following treatment of P. vivax malaria with artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) unless they are co-administered with primaquine. The research supports recommendations that these artemisinin-based combination therapies (ACT) should be combined with primaquine.

Science blog: All things Africa in Oxford: Africa Oxford Initiative

@Oxford

The Africa Oxford Initiative (AfOx) is a cross-university network that brings the University of Oxford’s long-standing, multi-disciplinary engagement with Africa under one platform. The overarching goal of AfOx is to ensure Africa remains a strategic priority for the University, and that students and academics who attend from the Continent feel supported and at home while they are here.

Nobel Prize for Medicine awarded to NDM Professor Sir Peter Ratcliffe

Awards & Appointments General

Professor Sir Peter J Ratcliffe, Director for the Target Discovery Institute within the Nuffield Department of Medicine at Oxford University and Director of Clinical Research at Francis Crick Institute, London, has today been announced as a winner of the Nobel Prize in Physiology or Medicine.

NEST360 partnership to reduce by half newborn mortality in sub-Saharan hospitals

@Oxford KWTRP Research

The Oxford based OHSCAR team is delighted to be a partner the NEST360 project working with KEMRI-Wellcome and the Kenya Paediatric Research Consortium in Kenya to support this effort to improve care care of the sick newborn and save lives

Oxford students celebrate Black History Month

@Oxford General

Oxford University is running a campaign to celebrate Black History Month. Throughout October the university will amplify the annual celebration with a series of content streams and events recognising and appreciating the contributions that BME communities make to society and the university itself. From academics to students, staff and alumni, the campaign will shine a light on black people’s achievements, and echo the growing call for inclusion in all areas of life from education to cultural appreciation.

Oxford Vice-Chancellor Louise Richardson visits MORU and SMRU

MORU

MORU and SMRU were delighted and honoured to host the University of Oxford Vice-Chancellor Prof Louise Richardson and her party during her visit to Thailand on 1-4 September. Accompanying the Vice-Chancellor were Jeremy Woodall (Director of Development (Asia)), Frewyeni Kidane (Fundraiser for Southeast Asia), Cher Wu (Asia Development office) and Ed Gibbs (NDM Director of Finance and Operations).

Report on the state of governance and coordination for health emergency preparedness and response

@Oxford Research

This report presents research on the current state of governance and coordination of health emergency preparedness and response. It highlights key challenges to address for the future. The report was commissioned by the Global Preparedness Monitoring Board to inform their inaugural report launched on 18th September 2019.

MORU's new Critical Care Asia Network: 42 ICUs in 9 countries

MORU Research

In partnership with the Wellcome Innovations Flagship Programme, MORU launched its Critical Care Asia Network project with its first investigators’ meeting on 19-20 Aug in Bangkok. The project will establish an Asian ICU network across 42 ICUs in nine countries and implement a setting-adapted electronic registry.

Oxford Tropical Medicine awarded two RSTMH medals

@Oxford Awards & Appointments KWTRP

Two researchers from the Centre for Tropical Medicine and Global Health were awarded medals by the Royal Society of Tropical Medicine and Hygiene at the 2019 European Congress on Tropical Medicine and International Health. Professor David Warrell was awarded the Sir Patrick Manson Medal, and Dr Samson Kinyanjui the Chalmers Medal.

Tungiasis (Jiggers): How remote village is winning the war

KWTRP Research

In Kenya, the poorest of the poor carry the highest burden of disease. From locally-made, low-cost herbal remedies to affordable hard floors for households, researchers and communities are developing new ways to deal with jiggers in Kenya. Lynne Elson, a research fellow at KEMRI Wellcome Trust, lead a study to determine whether neem and coconut oil reduce inflammation, pain and itching better than the standard treatment in seven days.

Oxford ranked world’s best university for fourth year running

Awards & Appointments General

Oxford has been named the world’s number one university for the fourth successive year in the Times Higher Education World University Rankings.

Malaria breakthrough as scientists find ‘highly effective’ way to kill parasite

KWTRP Research

Human trials of new antimalarial drugs are in the pipeline after KEMRI scientists successfully used bacteria to kill the parasite that causes the disease. Trials in Burkina Faso showed that Ivermectin, a conventional drug used for parasitic diseases including river blindness and elephantiasis, reduced transmission rates. The medication worked by making the blood of people who were repeatedly vaccinated lethal to mosquitoes. The study also found that Ivermectin can kill plasmodium falciparum, the malaria parasite carried by female mosquitoes, when administered to humans.

The 'impossible' job of being a neonatal nurse

KWTRP Publication Research

The provision of high-quality care to sick newborns presents challenges in any health system. International guidelines suggest that even for babies who do not require intensive care, there should be one nurse for every 2 – 4 sick babies. However, recent studies conducted in Nairobi show that one nurse takes care of between 20 – 40 newborns. In a recently published policy brief the KEMRI Wellcome Trust programme highlights the experience of nurses in Nairobi’s New Born Units.

New Chagas collaboration to aggregate and standardise data

@Oxford Research

IDDO has launched a new global Chagas scientific collaboration with the Drugs for Neglected Diseases initiative (DNDi). The new platform will collate and standardise data to accelerate better treatments for the 6–7 million people worldwide with Chagas disease.

Ongoing research at KWTRP Nairobi Hub

KWTRP Research

The Nairobi Programme at KEMRI Wellcome Trust Research Programme hosts over 17 principal researchers, 15 PhD fellows and a dedicated team of over 40 research assistants spanning clinical research, health services research, population health research, and health systems and economics research. Learn more about the ongoing research and the principal researchers behind the work.

Latest research finds primaquine improves haemoglobin by day 42 following treatment of P. vivax malaria

@Oxford Publication Research

An IDDO/WWARN study has found that primaquine is not associated with increased levels of anaemia following treatment of patients without G6PD deficiency for P. vivax malaria and should be used as part of a radical cure. In the largest study of its kind to date, researchers carried out a systematic review and individual patient data meta-analysis which involved 3,421 patients in 29 studies published in BMC Medicine.

Better Research for Better Health: University of Oxford and Fiocruz partner to improve health research and capacity development globally

@Oxford Research

A new strategic partnership between Fiocruz and The Global Health Network will amplify the impact of Fiocruz’s health research and capacity development initiatives by promoting research capacity building across Portuguese-speaking countries, and enabling research findings from the Zika outbreak to benefit public health worldwide.

Launch of comprehensive public health facility inventory for sub-Saharan Africa

KWTRP Publication Research

KWTRP has launched a dataset of comprehensive public health facilities from 50 countries in sub- Saharan Africa. This new dataset locates health facilities in relation to the communities they are intended to serve, to help ensure that services are accessible to the right populations and that no one is geographically marginalized from essential services. This is critical for attainment of Sustainable Development Goal 3 on good health and wellbeing.

Antimalarial treatments less effective in severely malnourished children

MORU Publication Research

MORU researchers have found that severe malnutrition is associated with lower exposure to the antimalarial drug lumefantrine in children treated with artemether-lumefantrine, the most common treatment for uncomplicated falciparum malaria. The study, which is the first to specifically address this, calls urgently for further research into optimised dosing regimens for undernourished children.

Rapidly spreading multidrug-resistant parasites render frontline malaria drug ineffective in southeast Asia

MORU Publication Research

The findings of two studies, published in The Lancet Infectious Diseases journal, reveal that by 2016–2018 malaria parasites resistant to both artemisinin and its widely used partner drug piperaquine represented more than 80% of the parasites circulating in northeast Thailand and Vietnam, despite having only emerged in western Cambodia in 2008.

New study shows faster way to cure vivax malaria

MORU Publication Research

A large clinical trial in Africa and Asia has shown that a 7 day course of high dose primaquine, a drug used to treat P. vivax malaria, is well tolerated and just as effective as the current standard 14 day regimen, according to a study published this week in The Lancet. These findings have important implications for the treatment and elimination of vivax malaria in the Asia Pacific.

Research to investigate the prevalence and causes of rickets in remote NW Myanmar

MORU Research

Medical Action Myanmar and MOCRU health teams identified a number of children with rickets in remote areas of Myanmar. MOCRU director Frank Smithuis presented the findings of clinical screening to the Minister of Health, alongside treatment results and a plan for a large survey to investigate the prevalence of vitamin D deficiency and its underlying causes.

Bringing science and health research to Kenyan schools project wins University Public Engagement with Research Award

Awards & Appointments KWTRP Public Engagement

A project bringing science to Kenyan schools, led by Dr Alun Davis from Kemri Wellcome Trust Research Programme in Kenya and Nuffield Department of Medicine, has won a Project Award in this year’s Vice-Chancellor’s Public Engagement with Research Awards.

Village drama against malaria project wins University Public Engagement with Research Award

Awards & Appointments MORU Public Engagement

A project using drama that engages with village communities in Cambodia, led by Professor Phaik Yeong Cheah of the Mahidol Oxford Tropical Medicine Research Unit and Nuffield Department of Medicine, has won a Project award in this year’s Vice-Chancellor’s Public Engagement with Research Awards. The project also won the Vice-Chancellor’s Choice Award for Public Engagement with Research.

Longer follow-up needed for malaria treatment in pregnant women

MORU Publication Research

New research by Makoto Saito and colleagues at SMRU found that a longer follow-up is required to assess antimalarial drug efficacy in pregnant women. This was found across all drugs assessed in low malaria transmission settings. The report’s authors have called for guidelines specifically for pregnant women and further investigation of optimal follow-up periods in high malaria transmission settings.

IDDO announces new research activities for visceral leishmaniasis

@Oxford Research

IDDO’s visceral leishmaniasis (VL) collaboration is working on two new projects looking at the treatment of VL. The first is a systematic review of the literature on design and analysis of antileishmanial clinical efficacy studies, and the second is a systematic review of published studies to estimate the baseline risk of serious adverse events and mortality in patients treated with antileishmanial therapies.

Malaria no more UK: Debashish Das' story

@Oxford Research

WWARN Researcher Debashish Das has been involved in clinical research in various settings in Asia and Africa with the Mahidol-Oxford Tropical Medicine Research Unit (MORU) and Médecins Sans Frontières (MSF). His research efforts focus on investigating antimalarial drug resistance and finding treatment solutions for young children

Need for better community engagement during global health emergencies

@Oxford Conferences & meetings

A workshop held in Dakar, Senegal, 7-18 March, highlighted the need for better community engagement during global health emergencies. An international group of experts in community engagement for health research identified urgent measures to foster involvement of local communities in emergency research, such as the Ebola outbreak in Democratic Republic of Congo.

BBC News: Big data 'can stop malaria outbreaks before they start'

MORU Publication Research

A ground-breaking study in Bangladesh co-lead by MORU has found that using data from mobile phone networks to track the movement of people across the country can help predict where outbreaks of diseases such as malaria are likely to occur, enabling health authorities to take preventative measures.

New statistical approaches for estimating antimalarial drug efficacy

@Oxford Research

WWARN’s Clinical Scientific Group have published research in BMC Medical Research Methodology comparing different statistical approaches for deriving cumulative estimates of drug efficacy from clinical studies. Results indicate that the Cumulative Incidence Function (CIF) approach should be considered as an alternative to the widely used Kaplan-Meier method for calculating efficacy estimates in high transmission areas.

Bangkok Premiere of Under the Mask

MORU Public Engagement

MORU, SMRU and FilmAid Foundation invite you to the Bangkok Premiere of Under the Mask on the 17th June. This drama film is based on real testimonies of TB patients. The story follows the lives of our characters as they journey from diagnosis to treatment and help from the SMRU TB team, and explores how each discovers their capacity to overcome the deadly disease and share their knowledge and experience with others. Made in the local language, this film provides an engaging and inspiring tool for raising TB awareness in the community.

AfOx in Blueprint, Oxford University staff magazine

@Oxford Research

Avni Gupta, Communications Officer for AfOx, talks about the work of this university-wide initiative – which brings the University’s long-standing multi-disciplinary engagement with Africa under one platform

The importance of community involvement in tackling Ebola

@Oxford Public Engagement

In this letter co-signed by Peter Horby and Vicki Marsh, researchers stress the importance of building trusting relationships with communities affected by ebola. As shown in DRC, trust is not a given, which is one of the reasons why community engagement – involving local people in the development of the response from the very start – is so important. In conflict zones this is more difficult than in other emergencies, and yet even more important.

New Data Access Committee begins work on Ebola

@Oxford Research

IDDO Ebola Data Platform, a pioneering collaboration in Ebola and emerging infections, has today appointed nine members for its first Data Access Committee, overseen and chaired by TDR, the Special Programme for Research and Training in Tropical Diseases, hosted at WHO.

Pint of Science Thailand 2019 in Bangkok and Chiang Rai

MORU Public Engagement

This year, the Pint of Science festival in Thailand is in not one but two cities! Join us in Bangkok at WeLearn on 21st-22nd May, and at Hungry Wolf's in Chiang Rai on 25th May.

Join SMRU for Hand Hygiene Day

MORU Public Engagement

The 5th May is World Hand Hygiene Day. To raise awareness among staff and the Thai-Myanmar border populations of the importance of hand washing, a simple, proven effective way of infection prevention, the SMRU infection control committee worked with the SMRU clinics and Mae Sot lab staff to create this fantastic video.

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