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Mapping malaria resistance using the act partner drug molecular surveyor

Mapping malaria resistance using the ACT Partner Drug Molecular Surveyor

@Oxford Research

In an article published in Malaria Journal, members of the WWARN Molecular Scientific and Informatics Group describe the development of WWARN’s ACT Partner Drug Molecular Surveyor. Launched in 2015, this online mapping tool supports the malaria community to track over nearly 20 years the prevalence of the molecular markers that are associated with antimalarial drug resistance.

New project to develop a mda vector control strategy to kill malaria transmitting mosquitoes

New project to develop a MDA vector control strategy to kill malaria-transmitting mosquitoes

KWTRP Research

Global efforts to fight malaria have hit a plateau and new tools are needed to achieve global goals. In this context, a consortium led by the Barcelona Institute for Global Health was awarded $25.3m from Unitaid (unitaid.org) to evaluate mass drug administration of ivermectin to humans and livestock in Tanzania and Mozambique, to kill the mosquitoes that transmit malaria. KWTRP Marta Maia will contribute as lead entomologist to BOHEMIA.

Afox travel grant leads to breakthrough research on zika virus in angola

AfOx Travel Grant leads to breakthrough research on Zika virus in Angola

@Oxford Research

Thanks to an AfOx Travel Grant, Sarah Hill and Nuno Faria from Oxford Department of Zoology travelled to Luanda, Angola, to sequence viruses that cause severe disease. The first genomes of Zika virus detected in patients in Angola were thus sequenced. This method can help reveal the ‘family tree’ of viruses and better understand how viruses spread across the world. The researchers have now started to sequence additional viral genomes, from dengue and yellow fever, for similar studies on these viruses.

Paul sondo from nanoro burkina faso recounts the highlights from his crdf fellowship at wwarn

Paul Sondo from Nanoro, Burkina Faso, recounts the highlights from his CRDF Fellowship at WWARN

@Oxford Research

Paul Sondo, molecular parasitologist from the Clinical Research Unit of Nanora in Burkina Faso, spent the last 12 months with WWARN as a recipient of the Clinical Research and Development Fellowship. He tells us about his experience as a CRDF Fellow and how it is starting to impact on his clinical research back at the Clinical Research Unit of Nanora.

Mass drug administration against malaria seen effective

Mass drug administration against malaria seen effective

MORU Research

Lorenz Von Seidlein tells SciDev.Net that mass drug administration as “presumptive treatment” to clear the parasite reservoir was carried out in eight villages spread across Cambodia, Lao PDR, Myanmar and Vietnam. By the third month, the prevalence of P. falciparum had decreased by 92 % in those villages. Over the subsequent nine months, P. falciparum infections returned but stayed well below baseline levels, showing that MDA can stop transmission of falciparum malaria and reduce its prevalence in SE Asia, where resistance to artemisinin has hampered elimination efforts.

Katherine plewes earns canadian grant for kimoru based study

Katherine Plewes earns Canadian grant for KIMORU based study

MORU Research

Working closely with the University of British Columbia (UBC)'s Support Program to Advance Research Capacity (SPARC), MORU Malaria Researcher Dr Katherine Plewes was recently awarded a 3-year, C$971,551 grant for her study on Evaluating the renoprotective effect of acetaminophen in pediatric severe falciparum malaria: A randomized controlled trial.

Iddo launch schistosomiasis and sths platform

IDDO launch Schistosomiasis and STHs platform

@Oxford Research

IDDO launched a new global scientific collaboration dedicated to schistosomiasis and STHs with TDR (the Special Programme for Research and Training in Tropical Diseases). This aims to expand data re-use and collaboration and accelerate better treatment and control of these diseases, which affect more than a billion people globally.

Guide to sepsis management offers comprehensive practical advice for resource limited settings

Guide to sepsis management offers comprehensive, practical advice for resource-limited settings

MORU Publication

On 12 Feb 2019, Professor Arjen Dondorp published a new book: Sepsis Management in Resource-limited Settings. The result of a 3-year project led by MORU and the European Society of Intensive Care Medicine (ESICM), the book was written by critical care physicians from around the globe.

Afox travel grant recipient wins the greenwood africa award 2019

AfOx Travel Grant recipient wins the Greenwood Africa Award 2019

@Oxford Awards & Appointments

Dr Richard Idro is a Senior Lecturer at Makerere University and an Honorary Fellow at Oxford University’s Centre for Tropical Medicine and Global Health. He was been awarded the LSHTM Inaugural Greenwood Africa Award 2019. Dr Idro received an AfOx Travel Grant in 2018 to form a new collaboration between The Ethox Centre at the University of Oxford, KEMRI-Wellcome Trust at Kilifi, Kenya and Makerere University.

Detact study begins will develop two new safe malaria treatments

DeTACT study begins; will develop two new, safe malaria treatments

MORU Research

On 24-25 Jan 2019, investigators met in Bangkok to launch the Developing Triple Artemisinin-based Combination Therapies (DeTACT) Project. Led by MORU and funded by UKaid and the UK Department for International Development (DfID), DeTACT is a large, 14 site trial in 8 African and 5 Asian countries that will study the efficacy, safety and tolerability of two Triple Artemisinin Combination Therapy (TACT) combinations, using combinations of existing antimalarial drugs.

Isaric awarded ps4 5 million to tackle the global threat of epidemic infectious diseases

ISARIC awarded £4.5 million to tackle the global threat of epidemic infectious diseases

@Oxford Research

The International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) has been awarded £4.5 million to accelerate clinical research to prevent illness and deaths from epidemic infectious diseases. ISARIC is a world-wide, grass-roots consortium of clinical research networks, working together on epidemic infections such as pandemic influenza, Ebola, Lassa fever, and plague.

Kemri wellcome gemvi

Kemri Wellcome GeMVI

KWTRP Research

A new project at KEMRI Wellcome aims to bring high throughput pathogen sequencing and predictive models in East Africa. GeMVI plans to engage health authorities and institutes, identify priority questions and fund 20 Research Fellows on locally relevant projects. GeMVI will transfer sequencing technologies, share bioinformatic methods and develop modelling capacity, as well as generate new understanding through predictive modelling and virus sequence data.

Afox partners with ndm oxford to offer summer internships to students from africa

AfOx partners with NDM to offer summer internships to students from Africa.

@Oxford

AfOx, the Africa Oxford Initiative, has partnered with the Nuffield Department of Medicine to offer summer internships to undergraduate and Masters students from Africa. Students will get the opportunity to work in a lab environment and live in Oxford for 8 weeks!

Electronic health records a case study from kenya

Electronic Health Records: a case study from Kenya

@Oxford KWTRP Research

In this background report for the Pathways to Prosperity Commission, Chris Paton and Naomi Muinga describe the implementation of the new OpenMRS-based system called Afya (Swahili for ‘health’) Electronic Health Management System in Machakos County in Kenya. They assess the challenges associated with implementation, and suggest some recommendations for rolling out digital methods to keep clinical records in developing countries.

Ps20 million research hub could help african teens achieve their full potential

£20 million research hub could help African teens achieve their full potential

@Oxford

AfOx joins the University of Oxford to run the UKRI GCRF Accelerating Achievement for Africa’s Adolescents Hub. By 2050 Africa will be home to half a billion teenagers. Despite the incredible opportunity that such a vibrant pool of young potential presents, many of these teens will already be trapped in a cycle of poverty, violence, low education and poor health, by the time they reach adolescence. This new Hub aims to help them achieve their goals and aspirations.

Latest wwarn publication identifies 15 new mutant alleles in the kelch 13 gene

Latest WWARN publication identifies 15 new mutant alleles in the Kelch-13 gene

@Oxford Publication Research

A recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.

Fighting malaria in the remote reaches of cambodia

Fighting malaria in the remote reaches of Cambodia

MORU Research

Malaria causes nearly half a million deaths worldwide every year. Ninety percent of them are in sub-Saharan Africa, where poor infrastructure limits delivery of drugs. But now there is worry that those drugs are losing effectiveness as disease strains become resistant. PBS News Hour special correspondent Fred de Sam Lazaro reports from Cambodia, where scientists are researching and tracking new outbreaks.

Malaria in cambodia on sky news

Malaria in Cambodia on Sky News

MORU Research

Doctors in Northern Cambodia are trialling a new drug combination therapy in a bid to stop the spread of drug resistant strains of malaria.

Congratulations to jeremy farrar knighted in the new years honours 2019

Congratulations to Jeremy Farrar, knighted in the New Year's Honours 2019.

Awards & Appointments OUCRU

Director of Wellcome since 2013, Jeremy Farrar was previously Director of our OUCRU Vietnam programme for 18 years. He has published almost 600 peer-reviewed scientific papers, and mentored many dozens of students and fellows. These honours recognise the outstanding commitment and contribution Jeremy has made to science and medicine, and to improving health for individuals and communities globally.

Congratulations to abhilasha karkey astmh 2018 alan j magill fellowship recipient

Congratulations to Abhilasha Karkey, ASTMH 2018 Alan J. Magill Fellowship Recipient

Awards & Appointments OUCRU

Abhilasha Karkey, medical microbiologist at our OUCRU Unit in Kathmandu, Nepal, received the 2018 Magill Fellowship at the ASTMH conference in New Orleans. "Persistent gender inequality in science has severely limited women from achieving their potential to effectively contribute to scientific knowledge. I would like to grow as a leader and thereby encourage and inspire other scientists – especially women in South Asia."

Lancet highlight 2018 walking out of the shadows leprosy care in bangladesh

Lancet Highlight 2018: Walking out of the shadows: leprosy care in Bangladesh

OUCRU Publication

A photo from Pearl Gan, Photographer In Residence for OUCRU, was selected for The Lancet Highlights 2018. The picture shows Senior Nurse Shikh Rema changing the dressing for Jabeda Begom, a 65-year-old woman with leprosy, at the Jalchatra Hospital in Bangladesh. Treatment of leprosy is a lengthy process, but thanks to dedicated staff, patients are given the care and attention they need.

Sir david weatherall 1933 2018

Sir David Weatherall, 1933-2018

@Oxford MORU

An inspiring doctor and scientist of great compassion and intellect, Sir David Weatherall died 8 Dec 2018. A Nuffield Professor of Medicine, founder of the MRC Weatherall Institute of Molecular Medicine and a member of Wellcome’s Board throughout the 1990s, Sir David was instrumental in the creation of MORU back in 1979.

New study group to determine the effects of pregnancy on piperaquine pharmacokinetics

New Study Group to determine the effects of pregnancy on piperaquine pharmacokinetics

@Oxford

A new Piperaquine Pharmacokinetics in Pregnancy Study Group is now open for participation at WWARN. The analysis hopes to determine the effect of pregnancy on the pharmacokinetic (PK) properties of piperaquine and contribute evidence to inform decisions on the use and optimal dosing of piperaquine in pregnant women.

The large footprint of the centre for tropical medicine and global health

The large footprint of the Centre for Tropical Medicine and Global Health

@Oxford KWTRP MORU OUCRU

This article, written by Professor Nick Day at MORU and published in the November 2018 issue of the Oxford Alumni Newsletter, describes in a nutshell all the good work our Centre is doing to promote Global Oxford.

500 000 tghn e learning modules taken by 100 000 members

500,000 TGHN e-Learning modules taken by 100,000 members!

@Oxford

The Global Health Training Centre now has over 100,000 members across 196 countries who have taken over 500,000 e-Learning modules! Here’s what people say about our most popular courses

Afox visiting fellowships 2019 program now open for applications

AfOx 2019 Visiting Fellowships Programme now open for applications

@Oxford

The Africa Oxford Initiative (AfOx) invites applications for the 2019 AfOx Visiting Fellowships Programme. Our programme is designed to enhance academic mobility and network building. We support African scholars and researchers working over various areas to spend periods of flexible time in Oxford.

After mqph 2018 new collaborations to fight substandard medicines

After MQPH 2018, new collaborations to fight substandard medicines

@Oxford Conferences & meetings MORU

Over 200 delegates travelled from more than 50 countries to attend the first ever conference on Medicine Quality and Public Health (MQPH 2018) in Oxford from 23-28 Sept. The conference, at Keble College, brought together experts in pharmacy, public health, chemistry, law, sociology, governance and ethics, from medicines regulatory authorities, academia, pharmaceutical industry, NGOs, and international organisations.

Professor bob snow elected fellow of the african academy of sciences

Professor Bob Snow elected Fellow of the African Academy of Sciences

Awards & Appointments KWTRP

Congratulations to Bob Snow, Oxford Professor of Malaria Epidemiology, elected this month Fellow of the African Academy of Sciences. The AAS nominates and elects individuals who have excelled in their fields of expertise as fellows and gives prizes to recognise scientists who have contributed to developing their fields in Africa.

The fight against malaria has reached a standstill

The fight against malaria has reached a standstill

MORU Research

Progress against malaria has stalled, and the disease remains a significant threat to billions of people despite the expensive, decades-long efforts to contain it. In an encouraging development, MORU reported complete success in curing hundreds of patients in Southeast Asia with new three-drug combinations mixing fast-acting artemisinin with two longer-lasting drugs. It it hoped that triple therapy should become the standard for malaria treatment.

Art exhibition on fake medicine the disease of greed

Art exhibition on Fake Medicine, the disease of greed

@Oxford Conferences & meetings Public Engagement

Visit the Radcliffe Science Library before 4th January 2019 to see a new art exhibition of 14 prints illustrating the global health impact of poor quality medicines. The proliferation of poor quality medicines is an important but neglected public health problem, threatening millions of people all over the world, both in developing and wealthy countries.

Oxford retains top spot for medicine for eighth consecutive year

Oxford retains top spot for medicine for eighth consecutive year

Awards & Appointments General

Oxford University has been ranked as the world's best institution for medical and health teaching and research in the Times Higher Education World University Rankings for the eighth consecutive year. This ranking is based on criteria measuring teaching, research, industry income, international outlook and citations. It was noted that both research and clinical trials are supported by our network of international research units in Africa and Asia.

Reviewing the cardiovascular safety profile of antimalarial drugs

Reviewing the Cardiovascular Safety Profile of Antimalarial Drugs

MORU Publication Research

A systematic review analyses the results of 177 trials conducted between 1982 and 2016, including 18,436 patients who underwent electrocardiographic evaluation during malaria clinical trials. Nick White and colleagues found that serious cardiovascular side effects, which include sudden cardiac death, are very rare in the treatment of malaria with quinoline antimalarials. The work emphasises the importance of continued pharmacovigilance with the increasing use of quinoline antimalarials in mass treatment strategies such as intermittent preventative treatment and mass drug administration.

Positive results in fight against malaria in remote parts of myanmar

Positive results in fight against malaria in remote parts of Myanmar

MORU Research

The incidence of malaria has continued to drop dramatically in remote rural villages in Myanmar after community workers trained only to detect and treat malaria began providing basic health care as well as malaria services, researchers affiliated with MOCRU, our Myanmar-Oxford Clinical Research Unit, have said.

Fake drugs the global industry putting your life at risk

Fake drugs: the global industry putting your life at risk

@Oxford Conferences & meetings MORU Publication

The manufacture and distribution of medicines is a global industry, tainted by fake and substandard products. Not only might these drugs not work as expected, but some are even contributing to antimicrobial resistance. So, what’s in your medicine cabinet? This is an article on Mosaic, a Wellcome publication

The oxford statement lets demand medicines we can trust

The Oxford Statement - lets demand medicines we can trust

@Oxford Conferences & meetings MORU Publication

Every person has the right to expect that when they use a medical product, whether medicine, vaccine or diagnostic kit, it works. But too often, that is not the case. Substandard medical products result from errors, negligence or poor practice in manufacturing, transportation and/or storage. In contrast, falsified products result from criminal fraud. Both innovative and generic products are affected.

Sparking new collaboration and multi stakeholder discussion on substandard and falsified medicines at mqph 2018

Sparking collaborations and discussions on substandard and falsified medicines at MQPH 2018

@Oxford Conferences & meetings MORU

Over 200 delegates traveled from more than 50 countries to attend the first ever conference on Medicine Quality and Public Health (MQPH) in Oxford from 23-28 September 2018. The conference brought together experts from academia, public health, pharmacy, chemistry, law, ethics, social sciences, public engagement, health policy, with national medicines regulatory authorities, NGOs, international organizations and donors. Conference partners presented the latest evidence on substandard, falsified and unregulated medicines, and discussed strategies to tackle this global challenge.

Centre for tropical medicine and global health nominated for mrs prize

Centre for Tropical Medicine and Global Health nominated for MRS prize

Awards & Appointments MORU

CTMGH have been nominated for the Market Research Society President's Medal, awarded annually to an organisation that conduct extraordinary research but who might not be recognised through the usual channels. Our Centre is noted for its ingenious use of freely available online satellite images to gath data on the use of antibiotics in unmapped and inaccessible villages in rural Thailand and Laos. Researchers use the images to identify representative clusters of potential participants.

Provide basic health services in remote villages to eliminate malaria

Provide basic health services in remote villages to eliminate malaria

MORU Research

The incidence of malaria cases continued to drop dramatically in rural and remote Myanmar villages after community workers trained only to detect and treat malaria began providing basic health care as well as malaria services. Adding the health services to malaria control benefitted the villagers access to health and improved malaria services – paving the way for malaria elimination.

Global health by the pint

Global health by the pint

MORU Public Engagement

Come and meet us at the ASTMH conference, to enjoy science over a pint and bite to eat: Outbreaks, from Ebola to Zika on Mon 29th Oct. Mosquitoes, the most dangerous animals in the world on Tue 30th. Global health terror night: bats, mites and other creepy crawlies on Wed 31st. We will be at The Vintage, 3121 Magazine St, New Orleans, 7-9pm

Faith osier ted talk

Faith Osier TED talk

KWTRP Research Video

Professor Faith Osier's TED talk, accepted in April 2018, is now published as one of few by the TED Fellows Talks. The malaria vaccine was invented more than a century ago, yet each year hundreds of thousands of people still die from the disease. How can we improve this vital vaccine? In this informative talk, Faith shows how she combines cutting-edge technology with century-old insights in the hopes of creating a new vaccine that would eradicate malaria once and for all.

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