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Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control.

Kobylinski KC., Alout H., Foy BD., Clements A., Adisakwattana P., Swierczewski BE., Richardson JH.

Recently there have been calls for the eradication of malaria and the elimination of soil-transmitted helminths (STHs). Malaria and STHs overlap in distribution, and STH infections are associated with increased risk for malaria. Indeed, there is evidence that suggests that STH infection may facilitate malaria transmission. Malaria and STH coinfection may exacerbate anemia, especially in pregnant women, leading to worsened child development and more adverse pregnancy outcomes than these diseases would cause on their own. Ivermectin mass drug administration (MDA) to humans for malaria parasite transmission suppression is being investigated as a potential malaria elimination tool. Adding albendazole to ivermectin MDAs would maximize effects against STHs. A proactive, integrated control platform that targets malaria and STHs would be extremely cost-effective and simultaneously reduce human suffering caused by multiple diseases. This paper outlines the benefits of adding albendazole to ivermectin MDAs for malaria parasite transmission suppression.

More information Original publication

DOI

10.4269/ajtmh.14-0187

Type

Journal article

Publication Date

2014-10-01T00:00:00+00:00

Volume

91

Pages

655 - 662

Total pages

7

Addresses

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Keywords

Animals, Humans, Anopheles, Trichuris, Ascaris lumbricoides, Plasmodium falciparum, Malaria, Falciparum, Albendazole, Ivermectin, Soil, Antiparasitic Agents, Drug Therapy, Combination, Insect Vectors, Drug Synergism