Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
Gaillard T., Sriprawat K., Briolant S., Wangsing C., Wurtz N., Baragatti M., Lavina M., Pascual A., Nosten F., Pradines B.
ABSTRACT Determinations of doxycycline 50% inhibitory concentrations (IC 50 ) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC 50 s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC 50 s versus the group with high IC 50 s with regard to copy numbers of the Plasmodium falciparum tetQ ( pftetQ ) gene ( P = 0.11) or pfmdt gene ( P = 0.87) or the number of PfTetQ KYNNNN repeats ( P = 0.72).