Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults.

Cooper DJ., McQuilten ZK., Nichol A., Ady B., Aubron C., Bailey M., Bellomo R., Gantner D., Irving DO., Kaukonen K-M., McArthur C., Murray L., Pettilä V., French C., TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group .

BackgroundIt is uncertain whether the duration of red-cell storage affects mortality after transfusion among critically ill adults.MethodsIn an international, multicenter, randomized, double-blind trial, we assigned critically ill adults to receive either the freshest available, compatible, allogeneic red cells (short-term storage group) or standard-issue (oldest available), compatible, allogeneic red cells (long-term storage group). The primary outcome was 90-day mortality.ResultsFrom November 2012 through December 2016, at 59 centers in five countries, 4994 patients underwent randomization and 4919 (98.5%) were included in the primary analysis. Among the 2457 patients in the short-term storage group, the mean storage duration was 11.8 days. Among the 2462 patients in the long-term storage group, the mean storage duration was 22.4 days. At 90 days, there were 610 deaths (24.8%) in the short-term storage group and 594 (24.1%) in the long-term storage group (absolute risk difference, 0.7 percentage points; 95% confidence interval [CI], -1.7 to 3.1; P=0.57). At 180 days, the absolute risk difference was 0.4 percentage points (95% CI, -2.1 to 3.0; P=0.75). Most of the prespecified secondary measures showed no significant between-group differences in outcome.ConclusionsThe age of transfused red cells did not affect 90-day mortality among critically ill adults. (Funded by the Australian National Health and Medical Research Council and others; TRANSFUSE Australian and New Zealand Clinical Trials Registry number, ACTRN12612000453886 ; ClinicalTrials.gov number, NCT01638416 .).

More information Original publication

DOI

10.1056/nejmoa1707572

Type

Journal article

Publication Date

2017-11-01T00:00:00+00:00

Volume

377

Pages

1858 - 1867

Total pages

9

Addresses

F, r, o, m, , t, h, e, , A, u, s, t, r, a, l, i, a, n, , a, n, d, , N, e, w, , Z, e, a, l, a, n, d, , I, n, t, e, n, s, i, v, e, , C, a, r, e, , R, e, s, e, a, r, c, h, , C, e, n, t, r, e, ,, , S, c, h, o, o, l, , o, f, , P, u, b, l, i, c, , H, e, a, l, t, h, , a, n, d, , P, r, e, v, e, n, t, i, v, e, , M, e, d, i, c, i, n, e, ,, , M, o, n, a, s, h, , U, n, i, v, e, r, s, i, t, y, , (, D, ., J, ., C, ., ,, , Z, ., K, ., M, ., ,, , A, ., N, ., ,, , B, ., A, ., ,, , C, ., A, ., ,, , M, ., B, ., ,, , R, ., B, ., ,, , D, ., G, ., ,, , K, ., -, M, ., K, ., ,, , L, ., M, ., ,, , C, ., F, ., ), ,, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , I, n, t, e, n, s, i, v, e, , C, a, r, e, ,, , A, l, f, r, e, d, , H, o, s, p, i, t, a, l, , (, D, ., J, ., C, ., ,, , A, ., N, ., ,, , D, ., G, ., ), ,, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , H, a, e, m, a, t, o, l, o, g, y, ,, , M, o, n, a, s, h, , H, e, a, l, t, h, , (, Z, ., K, ., M, ., ), ,, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , I, n, t, e, n, s, i, v, e, , C, a, r, e, ,, , A, u, s, t, i, n, , H, o, s, p, i, t, a, l, , (, R, ., B, ., ), ,, , t, h, e, , U, n, i, v, e, r, s, i, t, y, , o, f, , M, e, l, b, o, u, r, n, e, , (, R, ., B, ., ,, , C, ., F, ., ), ,, , R, e, s, e, a, r, c, h, , a, n, d, , D, e, v, e, l, o, p, m, e, n, t, ,, , A, u, s, t, r, a, l, i, a, n, , R, e, d, , C, r, o, s, s, , B, l, o, o, d, , S, e, r, v, i, c, e, , (, D, ., O, ., I, ., ), ,, , a, n, d, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , I, n, t, e, n, s, i, v, e, , C, a, r, e, ,, , W, e, s, t, e, r, n, , H, e, a, l, t, h, , (, C, ., F, ., ), , -, , a, l, l, , i, n, , M, e, l, b, o, u, r, n, e, ,, , V, I, C, ,, , A, u, s, t, r, a, l, i, a, ;, , I, r, i, s, h, , C, r, i, t, i, c, a, l, , C, a, r, e, , C, l, i, n, i, c, a, l, , T, r, i, a, l, s, , N, e, t, w, o, r, k, ,, , U, n, i, v, e, r, s, i, t, y, , C, o, l, l, e, g, e, , D, u, b, l, i, n, , C, l, i, n, i, c, a, l, , R, e, s, e, a, r, c, h, , C, e, n, t, r, e, , a, t, , S, t, ., , V, i, n, c, e, n, t, ', s, , U, n, i, v, e, r, s, i, t, y, , H, o, s, p, i, t, a, l, ,, , D, u, b, l, i, n, , (, A, ., N, ., ), ;, , t, h, e, , D, é, p, a, r, t, e, m, e, n, t, , d, e, , M, é, d, e, c, i, n, e, , I, n, t, e, n, s, i, v, e, , R, é, a, n, i, m, a, t, i, o, n, ,, , B, r, e, s, t, , U, n, i, v, e, r, s, i, t, y, , H, o, s, p, i, t, a, l, ,, , B, r, e, s, t, ,, , F, r, a, n, c, e, , (, C, ., A, ., ), ;, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , A, n, e, s, t, h, e, s, i, o, l, o, g, y, , (, K, ., -, M, ., K, ., ), , a, n, d, , t, h, e, , D, i, v, i, s, i, o, n, , o, f, , I, n, t, e, n, s, i, v, e, , C, a, r, e, ,, , D, e, p, a, r, t, m, e, n, t, , o, f, , A, n, e, s, t, h, e, s, i, o, l, o, g, y, , (, V, ., P, ., ), ,, , I, n, t, e, n, s, i, v, e, , C, a, r, e, , a, n, d, , P, a, i, n, , M, e, d, i, c, i, n, e, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , H, e, l, s, i, n, k, i, , a, n, d, , H, e, l, s, i, n, k, i, , U, n, i, v, e, r, s, i, t, y, , H, o, s, p, i, t, a, l, ,, , H, e, l, s, i, n, k, i, ;, , a, n, d, , t, h, e, , M, e, d, i, c, a, l, , R, e, s, e, a, r, c, h, , I, n, s, t, i, t, u, t, e, , o, f, , N, e, w, , Z, e, a, l, a, n, d, , a, n, d, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , C, r, i, t, i, c, a, l, , C, a, r, e, , M, e, d, i, c, i, n, e, ,, , A, u, c, k, l, a, n, d, , C, i, t, y, , H, o, s, p, i, t, a, l, ,, , A, u, c, k, l, a, n, d, ,, , N, e, w, , Z, e, a, l, a, n, d, , (, C, ., M, ., ), .

Keywords

TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Humans, Critical Illness, Blood Preservation, Treatment Outcome, Erythrocyte Transfusion, Transplantation, Homologous, Double-Blind Method, Time Factors, Adult, Middle Aged, Female, Male, Intention to Treat Analysis, Kaplan-Meier Estimate