28 June 2019
IDDO’s visceral leishmaniasis (VL) collaboration is working on two new projects looking at the treatment of VL. The first is a systematic review of the literature on design and analysis of antileishmanial clinical efficacy studies, and the second is a systematic review of published studies to estimate the baseline risk of serious adverse events and mortality in patients treated with antileishmanial therapies.
14 June 2019
WWARN Researcher Debashish Das has been involved in clinical research in various settings in Asia and Africa with the Mahidol-Oxford Tropical Medicine Research Unit (MORU) and Médecins Sans Frontières (MSF). His research efforts focus on investigating antimalarial drug resistance and finding treatment solutions for young children
12 June 2019
A workshop held in Dakar, Senegal, 7-18 March, highlighted the need for better community engagement during global health emergencies. An international group of experts in community engagement for health research identified urgent measures to foster involvement of local communities in emergency research, such as the Ebola outbreak in Democratic Republic of Congo.
5 June 2019
WWARN’s Clinical Scientific Group have published research in BMC Medical Research Methodology comparing different statistical approaches for deriving cumulative estimates of drug efficacy from clinical studies. Results indicate that the Cumulative Incidence Function (CIF) approach should be considered as an alternative to the widely used Kaplan-Meier method for calculating efficacy estimates in high transmission areas.
24 May 2019
Avni Gupta, Communications Officer for AfOx, talks about the work of this university-wide initiative – which brings the University’s long-standing multi-disciplinary engagement with Africa under one platform
24 May 2019
In this letter co-signed by Peter Horby and Vicki Marsh, researchers stress the importance of building trusting relationships with communities affected by ebola. As shown in DRC, trust is not a given, which is one of the reasons why community engagement – involving local people in the development of the response from the very start – is so important. In conflict zones this is more difficult than in other emergencies, and yet even more important.
17 May 2019
IDDO Ebola Data Platform, a pioneering collaboration in Ebola and emerging infections, has today appointed nine members for its first Data Access Committee, overseen and chaired by TDR, the Special Programme for Research and Training in Tropical Diseases, hosted at WHO.
3 May 2019
This 5-day course is aimed at participants with a basic understanding of infectious disease modelling and an aptitude for the R programming language. On completion participants will be able to write and analyse the dynamics of a simple mathematical model and use it to consider cost and intervention scenarios. September 23-27 at St Anne’s College, Oxford
30 April 2019
To mark World Malaria Day on 25 April WWARN’s Dr Makoto Saito and Professor Joel Tarning from the Mahidol Oxford Tropical Medicine Research Unit and Head of WWARN Pharmacometrics presented their work on prevention and treatment of malaria in vulnerable groups at a seminar hosted by the Centre for Tropical Medicine and Global Health
Widely used malaria treatment to prevent malaria in pregnant women at risk of failing in areas where drug resistance is rising
26 March 2019
A global team of researchers, led by a research team at the Liverpool School of Tropical Medicine (LSTM), are calling for a review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.
12 March 2019
In an article published in Malaria Journal, members of the WWARN Molecular Scientific and Informatics Group describe the development of WWARN’s ACT Partner Drug Molecular Surveyor. Launched in 2015, this online mapping tool supports the malaria community to track over nearly 20 years the prevalence of the molecular markers that are associated with antimalarial drug resistance.
6 March 2019
Thanks to an AfOx Travel Grant, Sarah Hill and Nuno Faria from Oxford Department of Zoology travelled to Luanda, Angola, to sequence viruses that cause severe disease. The first genomes of Zika virus detected in patients in Angola were thus sequenced. This method can help reveal the ‘family tree’ of viruses and better understand how viruses spread across the world. The researchers have now started to sequence additional viral genomes, from dengue and yellow fever, for similar studies on these viruses.
6 March 2019
Paul Sondo, molecular parasitologist from the Clinical Research Unit of Nanora in Burkina Faso, spent the last 12 months with WWARN as a recipient of the Clinical Research and Development Fellowship. He tells us about his experience as a CRDF Fellow and how it is starting to impact on his clinical research back at the Clinical Research Unit of Nanora.
1 March 2019
IDDO launched a new global scientific collaboration dedicated to schistosomiasis and STHs with TDR (the Special Programme for Research and Training in Tropical Diseases). This aims to expand data re-use and collaboration and accelerate better treatment and control of these diseases, which affect more than a billion people globally.
26 February 2019
Dr Richard Idro is a Senior Lecturer at Makerere University and an Honorary Fellow at Oxford University’s Centre for Tropical Medicine and Global Health. He was been awarded the LSHTM Inaugural Greenwood Africa Award 2019. Dr Idro received an AfOx Travel Grant in 2018 to form a new collaboration between The Ethox Centre at the University of Oxford, KEMRI-Wellcome Trust at Kilifi, Kenya and Makerere University.
8 February 2019
The International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) has been awarded £4.5 million to accelerate clinical research to prevent illness and deaths from epidemic infectious diseases. ISARIC is a world-wide, grass-roots consortium of clinical research networks, working together on epidemic infections such as pandemic influenza, Ebola, Lassa fever, and plague.
5 February 2019
AfOx, the Africa Oxford Initiative, has partnered with the Nuffield Department of Medicine to offer summer internships to undergraduate and Masters students from Africa. Students will get the opportunity to work in a lab environment and live in Oxford for 8 weeks!
1 February 2019
In this background report for the Pathways to Prosperity Commission, Chris Paton and Naomi Muinga describe the implementation of the new OpenMRS-based system called Afya (Swahili for ‘health’) Electronic Health Management System in Machakos County in Kenya. They assess the challenges associated with implementation, and suggest some recommendations for rolling out digital methods to keep clinical records in developing countries.
22 January 2019
AfOx joins the University of Oxford to run the UKRI GCRF Accelerating Achievement for Africa’s Adolescents Hub. By 2050 Africa will be home to half a billion teenagers. Despite the incredible opportunity that such a vibrant pool of young potential presents, many of these teens will already be trapped in a cycle of poverty, violence, low education and poor health, by the time they reach adolescence. This new Hub aims to help them achieve their goals and aspirations.
18 January 2019
A recent WWARN individual patient meta-analysis has gathered 18 published and unpublished studies from Africa and Asia to explore the relationships between identified Kelch 13 mutant alleles and delayed parasite clearance. The study results show one P. falciparum specific mutant and 20 pfk13 propeller region mutant alleles are strongly associated with the slow clearance phenotype, including 15 mutations that have not been confirmed before. It was reassuring that no pfk13 alleles associated with slow parasite clearance were observed in the parasites from African studies gathered between 2000-2017.
18 December 2018
An inspiring doctor and scientist of great compassion and intellect, Sir David Weatherall died 8 Dec 2018. A Nuffield Professor of Medicine, founder of the MRC Weatherall Institute of Molecular Medicine and a member of Wellcome’s Board throughout the 1990s, Sir David was instrumental in the creation of MORU back in 1979.
18 December 2018
A new Piperaquine Pharmacokinetics in Pregnancy Study Group is now open for participation at WWARN. The analysis hopes to determine the effect of pregnancy on the pharmacokinetic (PK) properties of piperaquine and contribute evidence to inform decisions on the use and optimal dosing of piperaquine in pregnant women.
12 December 2018
This article, written by Professor Nick Day at MORU and published in the November 2018 issue of the Oxford Alumni Newsletter, describes in a nutshell all the good work our Centre is doing to promote Global Oxford.
6 December 2018
The Global Health Training Centre now has over 100,000 members across 196 countries who have taken over 500,000 e-Learning modules! Here’s what people say about our most popular courses
6 December 2018
The Africa Oxford Initiative (AfOx) invites applications for the 2019 AfOx Visiting Fellowships Programme. Our programme is designed to enhance academic mobility and network building. We support African scholars and researchers working over various areas to spend periods of flexible time in Oxford.
21 November 2018
Over 200 delegates travelled from more than 50 countries to attend the first ever conference on Medicine Quality and Public Health (MQPH 2018) in Oxford from 23-28 Sept. The conference, at Keble College, brought together experts in pharmacy, public health, chemistry, law, sociology, governance and ethics, from medicines regulatory authorities, academia, pharmaceutical industry, NGOs, and international organisations.
16 November 2018
Visit the Radcliffe Science Library before 4th January 2019 to see a new art exhibition of 14 prints illustrating the global health impact of poor quality medicines. The proliferation of poor quality medicines is an important but neglected public health problem, threatening millions of people all over the world, both in developing and wealthy countries.
7 November 2018
The manufacture and distribution of medicines is a global industry, tainted by fake and substandard products. Not only might these drugs not work as expected, but some are even contributing to antimicrobial resistance. So, what’s in your medicine cabinet? This is an article on Mosaic, a Wellcome publication
7 November 2018
Every person has the right to expect that when they use a medical product, whether medicine, vaccine or diagnostic kit, it works. But too often, that is not the case. Substandard medical products result from errors, negligence or poor practice in manufacturing, transportation and/or storage. In contrast, falsified products result from criminal fraud. Both innovative and generic products are affected.
29 October 2018
Over 200 delegates traveled from more than 50 countries to attend the first ever conference on Medicine Quality and Public Health (MQPH) in Oxford from 23-28 September 2018. The conference brought together experts from academia, public health, pharmacy, chemistry, law, ethics, social sciences, public engagement, health policy, with national medicines regulatory authorities, NGOs, international organizations and donors. Conference partners presented the latest evidence on substandard, falsified and unregulated medicines, and discussed strategies to tackle this global challenge.
28 September 2018
In this Science blog, field researchers, Dr Giacomo Zanello, Dr Marco Haenssgen, Ms Nutcha Charoenboon and Mr Jeffrey Lienert explain the importance of continuing to improve survey research techniques when working in rural areas of developing countries.
Medicine Quality and Public Health, a pioneering conference to address the global threat of poor quality medicines
4 September 2018
A pioneering academic conference will bring together, for the first time, people from all over the world dealing with the problem of poor quality medicines and their impact on public health. The Medicine Quality & Public Health conference will take place at Keble College, Oxford, 23-28 Sept 2018. It will provide a unique opportunity for health authorities, scientists, pharmacists, lawyers and international organisations to discuss the problem and outline the necessary steps to tackle the issue on a global scale.
21 August 2018
The Antibiotics and Activity Spaces project is a survey of 4,800 villagers in Thailand and Lao PDR to better understand how people access healthcare and whether there are simple early warning indicators to detect 'problematic' antibiotic use. Marco J Haenssgen and colleagues recently hosted a photography exhibition in Bangkok on rare and vivid narratives of healing in Northern Thailand.
8 August 2018
Dr Chris Paton, Head of the Global Health Informatics Group, was accepted as Fellow by the Faculty of Clinical Informatics Council on 8th August 2018. Clinical informaticians are qualified clinicians who transform health and care through their specialist knowledge and use of data, information, knowledge and information technology.
3 July 2018
The Infectious Disease Data Observatory and The Global Health Network have signed a Wellcome joint statement, along with the Gates Foundation, Lancet, PLOS and others, to help ensure data on the current Ebola outbreak in the Democratic Republic of Congo is free to access and shared rapidly.
27 June 2018
Lessons learned from past Ebola epidemics are helping to combat a fresh outbreak in the Democratic Republic of Congo (DRC). Investing in new vaccines, diagnostic tests and laboratories is paying off as expert networks spring into action.
19 June 2018
Collecting representative survey data on large populations of people can be a very time-consuming and expensive undertaking. But it doesn’t have to be. Marco J. Haenssgen and Ern Charoenboon explain how they have used freely available satellite images to survey hard-to-reach communities in Thailand and Laos.
15 June 2018
The proliferation of poor quality medical products is an important but neglected public health problem, threatening millions of people all over the world, both in developing and wealthy countries. A pioneering conference will bring leading professionals from all over the world to Oxford, September 23-28, to discuss strategies for tackling poor quality medical products on a global scale.
23 May 2018
The first-ever dedicated academic conference to discuss Medicine Quality & Public Health bringing together people from a diversity of sectors: public health, national regulatory authority, pharmacy, biomedical, chemistry, law, ethics, cultural and social sciences, the pharmaceutical industry, international organisations, NGOs, national procurement centres, also scientists working on internet and pharmaceutical forensics. 23rd-28th September 2018 at Keble College, Oxford. Submit your abstract by 1 June 2018
11 May 2018
Dr Marco J Haenssgen discusses the application of management thinking to solving the growing global problem of antimicrobial resistance.
9 May 2018
The Royal Society recognises Professor Dominic Kwiatkowski’s pioneering work on malaria, and particularly the use of genomic epidemiology to understand the evolutionary arms race that is going on between human, parasite and mosquito populations in Africa and other tropical regions of the world. Professor Kwiatkowski joins an existing membership of approximately 1600 of the most distinguished scientists from the United Kingdom, other Commonwealth countries and the Republic of Ireland.
24 April 2018
Almost one in four blood bank supplies in certain regions of Africa may have malaria parasites in them. UK scientists reviewed 26 studies that measured levels of Plasmodium parasites among blood donors in sub-Saharan Africa between 2000 and 2017. Percentages varied greatly across the nine countries included in the study, ranging from 0% to as much as 74%, with an average of 23.46% tested positive.
13 March 2018
ERGO is launching ALERRT, a multi-disciplinary consortium building a patient-centered clinical research network to respond to epidemics across sub-Saharan Africa. ALERRT aims to reduce the public health and socio-economic impact of disease outbreaks in sub-Saharan Africa by building a sustainable clinical and laboratory research preparedness and response network.
9 March 2018
Research led by Dr Marco Haenssgen has revealed how the complex cultural and social environment in developing countries can complicate the use of new diagnostic technologies to fight the global superbug crisis.
9 February 2018
Applications are now being accepted for the AfOx Visiting Fellows Programme. This 4-6 weeks fellowship aims to facilitate collaborations, as well as foster research and teaching excellence in African institutions an the University of Oxford. Applicants must be residents of an African country and hold an appointment in an academic or research institution in an African country. Deadline 11th March 2018.
6 February 2018
Who will step up during the next decade to implement and integrate life-saving interventions and services for newborns? Decision-making leading to the implementation of newborn health services and interventions within broader health programmes requires multiple actors and levels of involvement. We invite you to contribute to the next phase of the discussion.
2 January 2018
Dr Jake Dunning, Honorary Visiting Research Fellow in Tropical Medicine (ERGO) and Deputy Programme Director for High Consequence Infectious Diseases, NHS England, is appointed MBE for services to Clinical Research. Dr Dunning led clinical trials during the terrible Ebola epidemic in West Africa.
8 December 2017
The Crossing Boundaries III forum on health systems research got off to an exciting start with a good number of guests in attendance. The two-day forum provided useful insights in ongoing research in low and middle income countries. Some of the topics discussed were on were on task shifting, interdisciplinary research methods, antimicrobial resistance, mental health and governance amongst others.