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<jats:p>We used controlled human malaria infection (CHMI) to study naturally acquired immunity of Kenyan adults. We administered 3.2x103 cryopreserved Plasmodium falciparum sporozoites (SPZ, NF54 West African strain) and undertook clinical monitoring and serial quantitative PCR (qPCR). Of the 142 volunteers who were eligible for analysis: 26 (18.3%) had febrile symptoms and were treated; 30 (21.1%) reached greater than or equal to 500 parasites/μl and were treated; 53 (37.3%) had parasitaemia without meeting thresholds for treatment and; 33 (23.2%) remained qPCR negative. We find that the immunity acquired by some Kenyan adults can completely suppress in vivo growth of a parasite strain originating from outside Kenya.</jats:p>

Original publication

DOI

10.1101/2020.08.11.20172411

Type

Publisher

Cold Spring Harbor Laboratory

Publication Date

11/08/2020