Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant
Mlcochova P., Collier D., Ritchie A., Assennato SM., Hosmillo M., Goel N., Meng B., Chatterjee K., Mendoza V., Temperton N., Kiss L., James LC., Ciazynska KA., Xiong X., Briggs JAG., Nathan JA., Mescia F., Bergamaschi L., Zhang H., Barmpounakis P., Demeris N., Skells R., Lyons PA., Bradley J., Baker S., Allain JP., Smith KGC., Bousfield R., Wilson M., Sparkes D., Amoroso G., Gkrania-Klotsas E., Hardwick S., Boyle A., Goodfellow I., Gupta RK., Baker S., Dougan G., Gupta R., Lehner PJ., Lyons P., Matheson NJ., Toshner M., Weekes MP., Brown N., Curran M., Palmar S., Enoch D., Chapman D., Shaw A., Jose S., Bermperi A., Zerrudo JA., Kourampa E., Watson L., Worsley J., Saunders C., de Jesus R., Domingo J., Pasquale C., Vergese B., Vargas P., Fabiculana M., Perales M., Mynott L., Blake E., Bates A., Vallier AL., Williams A., Phillips D., Chiu E., Overhill A., Ramenatte N., Sipple J., Frost S., Knock H., Hardy R., Foster E., Davidson F., Rundell V., Bundi P., Abeseabe R., Clark S., Vicente I., Elmer A., Ribeiro C., Kourampa J., Kennet J., Rowlands J., Meadows A., O'Brien C., Rastall R., Crucusio C., Hewitt S., Price J., Calder J., Canna L., Bucke A., Tordesillas H., Harris J.
Mlcochova et al. report that combined rapid nucleic acid amplification testing (NAAT) and finger prick blood antibody tests can substantially improve the diagnosis of COVID-19 as compared to NAAT alone and is able to detect the SARS-CoV-2 Spike D614G variant that dominates the pandemic.