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The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.

Original publication

DOI

10.1126/science.2658061

Type

Journal

Science (New York, N.Y.)

Publication Date

06/1989

Volume

244

Pages

1184 - 1186

Addresses

Department of Tropical Public Health Harvard School of Public Health, Boston, MA 02115.

Keywords

Animals, Mice, Plasmodium falciparum, Invertebrate Hormones, ATP-Binding Cassette Transporters, Protozoan Proteins, Nucleic Acid Hybridization, Gene Amplification, Amino Acid Sequence, Base Sequence, Sequence Homology, Nucleic Acid, Drug Resistance, Molecular Sequence Data