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This article reviews emerging Raman techniques (Spatially Offset and Transmission Raman Spectroscopy) for non-invasive, sub-surface probing in process control and forensic applications. New capabilities offered by these methods are discussed and several application examples are given including the non-invasive detection of counterfeit drugs through blister packs and opaque plastic bottles and the rapid quantitative analysis of the bulk content of pharmaceutical tablets and capsules without sub-sampling.

Original publication

DOI

10.1007/s11095-008-9587-2

Type

Journal

Pharmaceutical research

Publication Date

10/2008

Volume

25

Pages

2205 - 2215

Addresses

Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, UK.

Keywords

Capsules, Tablets, Spectrum Analysis, Raman, Technology, Pharmaceutical, Drug Contamination, Fraud, Forensic Sciences, Quality Control, Signal Processing, Computer-Assisted