Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 ofPlasmodium falciparum
Cavanagh DR., Dobaño C., Elhassan IM., Marsh K., Elhassan A., Hviid L., Khalil EATG., Theander TG., Arnot DE., McBride JS.
ABSTRACTComparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed toPlasmodium falciparumrevealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.