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The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01-.48]; P = .009), which warrants further studies to explore its role on HIV-1-specific immunopathogenesis.

Original publication

DOI

10.1093/ofid/ofae129

Type

Journal

Open forum infectious diseases

Publication Date

04/2024

Volume

11

Addresses

Lund University Centre, Lund University, Lund, Sweden.