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BACKGROUND: There is very little published data on the antibody response to the Vi capsular polysaccharide (Vi-CPS) of S. Typhi during naturally acquired typhoid fever in an endemic area. METHODOLOGY: An indirect ELISA, using tyraminated, purified Vi-CPS, was used to assay anti-Vi-CPS antibodies from typhoid fever cases and controls living in the Ho Chi Minh City and Mekong Delta region of Viet Nam. RESULTS: Antibody response to Vi-CPS is significantly higher in typhoid patients who have been ill for more than two weeks than those who are in the first two weeks of illness. The anti-Vi-CPS response is similar for adults and children. Anti-Vi-CPS antibodies can be detected in the sera of non-typhoid patients. The frequency with which this occurs increases with age, probably reflecting increased exposure to S. Typhi. CONCLUSIONS: Anti-Vi_CPS is elicited in persons infected with S. Typhi but only after a prolonged duration of illness. Vaccine trials have shown anti-Vi-CPS antibodies to be protective; thus early treatment of typhoid patients, i.e. in the first two week of illness before the Vi-CPS response is elicited, may inhibit the development of this protective immune response.

Type

Journal article

Journal

Journal of infection in developing countries

Publication Date

01/2008

Volume

2

Pages

308 - 312

Addresses

Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom.

Keywords

Humans, Salmonella typhi, Typhoid Fever, Polysaccharides, Bacterial, Antibodies, Bacterial, Enzyme-Linked Immunosorbent Assay, Case-Control Studies, Endemic Diseases, Age Factors, Adolescent, Adult, Child, Child, Preschool, Vietnam, Young Adult