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Thai patients with scrub typhus caused by the intracellular pathogen Orientia tsutsugamushi displayed elevated plasma concentrations of granzymes A and B, interferon-gamma (IFN)-gamma-inducible protein 10, and monokine induced by IFN-gamma. These data suggest that activation of cytotoxic lymphocytes is part of the early host response to scrub typhus.

Type

Journal article

Journal

The American journal of tropical medicine and hygiene

Publication Date

04/2005

Volume

72

Pages

465 - 467

Addresses

Laboratory of Experimental Internal Medicine and Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Keywords

T-Lymphocytes, Cytotoxic, Humans, Scrub Typhus, Chemokines, Case-Control Studies, Lymphocyte Activation, Adolescent, Adult, Middle Aged, Female, Male