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The contribution of malaria to morbidity and mortality among people in Africa has been a subject of academic interest, political advocacy, and speculation. National statistics for much of sub-Saharan Africa have proved to be an unreliable source of disease-specific morbidity and mortality data. Credible estimates of disease-specific burdens are required for setting global and national priorities for health in order to rationalize the use of limited resources and lobby for financial support. We have taken an empirical approach to defining the limits of Plasmodium falciparum transmission across the continent and interpolated the distributions of projected populations in 1995. By combining a review of the literature on malaria in Africa and models of acquired functional immunity, we have estimated the age-structured rates of the fatal, morbid and disabling sequelae following exposure to malaria infection under different epidemiological conditions.

Type

Journal

Bulletin of the World Health Organization

Publication Date

01/1999

Volume

77

Pages

624 - 640

Addresses

Kenya Medical Research Institute (KEMRI)/Wellcome Trust, Collaborative Programme, Nairobi, Kenya. bobsnow@wtrl.or.ke

Keywords

Humans, HIV Infections, Malaria, Cerebral, Malaria, Malaria, Falciparum, Anemia, Blood Transfusion, Risk Factors, Climate, Age Factors, Adolescent, Adult, Child, Child, Preschool, Infant, Infant, Newborn, Disabled Children, Africa, Africa, Northern, Africa South of the Sahara, Female, Male