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ABSTRACTMicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosalCitrobacter rodentiuminfection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higherC. rodentiumburden in gastrointestinal tissue and spread into systemic tissues. Germinal center formation and humoral immune responses againstC. rodentiumwere severely impaired in infected miR-155-deficient mice. A similarly susceptible phenotype was observed in μMT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen.

Original publication

DOI

10.1128/iai.00969-12

Type

Journal

Infection and Immunity

Publisher

American Society for Microbiology

Publication Date

03/2013

Volume

81

Pages

723 - 732