What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?
HORBY P., SUDOYO H., VIPRAKASIT V., FOX A., THAI PQ., YU H., DAVILA S., HIBBERD M., DUNSTAN SJ., MONTEERARAT Y., FARRAR JJ., MARZUKI S., HIEN NT.
<jats:title>SUMMARY</jats:title><jats:p>The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation.</jats:p>