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<jats:title>ABSTRACT</jats:title> <jats:p> In this study, using the Hain GenoType MTBDR <jats:italic>sl</jats:italic> assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in <jats:italic>gyrA</jats:italic> in <jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content> result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings. </jats:p>

Original publication

DOI

10.1128/aac.02169-16

Type

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

04/2017

Volume

61