Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine
Ippolito MM., Jacobson JM., Lederman MM., Winterberg M., Tarning J., Shapiro TA., Flexner C.
Abstract The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor–based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.