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Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.

Original publication

DOI

10.1038/ng.349

Type

Journal

Nature genetics

Publication Date

05/2009

Volume

41

Pages

521 - 523

Addresses

Wellcome Trust Sanger Institute, Hinxton, UK.

Keywords

Humans, Neoplasms, Oxidoreductases, N-Demethylating, Epigenesis, Genetic, Mutation, Jumonji Domain-Containing Histone Demethylases